Clascoterone: A New Topical Antiandrogen Agent

February 2025 in “ Prospects in Pharmaceutical Sciences ”

Magdalena Sitnik, Jakub Olszewski, M Bara, Piotr Armański, Katarzyna Herjan

clascoterone topical antiandrogen androgenetic alopecia dihydrotestosterone androgen receptors non-systemic treatment DHT

TLDR Clascoterone is a promising topical treatment for hair loss and acne with fewer side effects.

Clascoterone is a novel topical antiandrogen agent that has shown promise in the treatment of androgenetic alopecia and acne. The article discusses its mechanism of action, which involves blocking androgen receptors in the skin, thereby reducing the effects of dihydrotestosterone (DHT) that contribute to hair loss and acne. Clinical trials have demonstrated its efficacy and safety, with significant improvements observed in patients. The study highlights clascoterone's potential as a non-systemic treatment option, offering a favorable side effect profile compared to oral antiandrogens. This makes it a valuable addition to the therapeutic options for conditions driven by androgen activity.

View this study on prospects.wum.edu.pl →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

research Guidelines of Care for the Management of Acne Vulgaris

5 citations, January 2024 in “Journal of the American Academy of Dermatology”

Use benzoyl peroxide, retinoids, antibiotics, and isotretinoin for acne, and combine treatments for better results.

research Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics

17 citations, November 2021 in “Journal of Cosmetic Dermatology”

Combination therapies for androgenetic alopecia work best but can have significant side effects and costs.

research Androgens and Acne: Perspectives on Clascoterone, the First Topical Androgen Receptor Antagonist

9 citations, April 2021 in “Expert opinion on pharmacotherapy”

Clascoterone is a new, effective, and safe acne treatment without systemic side effects.

research Clascoterone as a Novel Treatment for Androgenetic Alopecia

5 citations, May 2020 in “Clinical and Experimental Dermatology”

Clascoterone may be a promising treatment for hair loss.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version

145 citations, November 2017 in “Journal of The European Academy of Dermatology and Venereology”

Use minoxidil for hair loss treatment; assess results after 6 months.

research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

178 citations, April 2017 in “Journal of The American Academy of Dermatology”

Minoxidil, finasteride, and low-level laser light therapy effectively treat hair loss.

research Androgenetic Alopecia: A Review

153 citations, March 2017 in “Endocrine”

Male pattern baldness involves genetics, hormones, and needs better treatments.

research A Review of Hormone-Based Therapies to Treat Adult Acne Vulgaris in Women

29 citations, March 2017 in “International Journal of Women's Dermatology”

Hormone therapies like birth control pills and spironolactone are safe and effective for treating women's adult acne.

research The Role of Androgen and Androgen Receptor in Skin-Related Disorders

124 citations, July 2012 in “Archives of Dermatological Research”

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

research Sexual Hormones in Human Skin

305 citations, February 2007 in “Hormone and metabolic research”

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Similar Research

5 / 42 results

Expanding The Therapeutic Versatility Of Clascoterone

Clascoterone: A New Topical Antiandrogen Agent

Research cited in this study

research Guidelines of Care for the Management of Acne Vulgaris

research Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics

research Androgens and Acne: Perspectives on Clascoterone, the First Topical Androgen Receptor Antagonist

research Clascoterone as a Novel Treatment for Androgenetic Alopecia

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version

research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

research Androgenetic Alopecia: A Review

research A Review of Hormone-Based Therapies to Treat Adult Acne Vulgaris in Women

research The Role of Androgen and Androgen Receptor in Skin-Related Disorders

research Sexual Hormones in Human Skin

Related Community Posts Join

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

community DHT Itch is real. The connection between Acne and Male Pattern Baldness shows this

community Why is dht bad for scalp hair but good for hair on the rest of body?

community CASSIOPEA ANNOUNCES VERY POSITIVE PHASE II TWELVE MONTHS RESULTS FOR BREEZULA® (CLASCOTERONE) IN TREATING ANDROGENETIC ALOPECIA

community 1 year on fin. No results. I give up.

Similar Research

research Expanding The Therapeutic Versatility Of Clascoterone

research Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris

research The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia

research Androgenetic Alopecia in Men: An Update on Genetics

research The Hormonal Background of Hair Loss in Non-Scarring Alopecias