Clascoterone: A New Topical Antiandrogen Agent

    February 2025 in “ Prospects in Pharmaceutical Sciences ”
    Magdalena Sitnik, Jakub Olszewski, M Bara … Katarzyna Herjan
    Studysummary This source reports that clascoterone cream, a topical androgen receptor inhibitor, has shown effectiveness in treating facial acne vulgaris in patients 12 and older, with clinical trials indicating a favorable safety profile compared to systemic treatments, and potential for broader dermatological applications.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 13

    1. Guidelines of Care for the Management of Acne Vulgaris Journal of the American Academy of Dermatology · 2024
    2. Use of Topical Clascoterone for the Treatment of Hidradenitis Suppurativa JAAD Case Reports · 2023
    3. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    4. Androgens and Acne: Perspectives on Clascoterone, the First Topical Androgen Receptor Antagonist Expert opinion on pharmacotherapy · 2021
    5. Clascoterone: First Approval Drugs · 2020
    6. Clascoterone as a Novel Treatment for Androgenetic Alopecia Clinical and Experimental Dermatology · 2020
    7. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version Journal of The European Academy of Dermatology and Venereology · 2017
    8. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    9. Androgenetic Alopecia: A Review Endocrine · 2017
    10. A Review of Hormone-Based Therapies to Treat Adult Acne Vulgaris in Women International Journal of Women's Dermatology · 2017
    11. The Role of Androgen and Androgen Receptor in Skin-Related Disorders Archives of Dermatological Research · 2012
    12. Sexual Hormones in Human Skin Hormone and metabolic research · 2007
    13. Evidence of Heterogeneity and Quantitative Differences of the Type 1 5α-Reductase Expression in Cultured Human Skin Cells: Evidence of Its Presence in Melanocytes Journal of Investigative Dermatology · 1998