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Glossary Topical Antiandrogens

medications applied to skin to block androgen effects locally

Topical antiandrogens are medications applied directly to the skin to block the effects of androgens, which are hormones that can contribute to conditions like acne, hirsutism (excessive hair growth), and androgenetic alopecia (pattern hair loss). By inhibiting these hormones locally, these treatments can help manage symptoms without the systemic side effects associated with oral antiandrogens.

Related Terms

Research

5 / 1000+ results

research RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism

49 citations , January 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that the topically applied non-steroidal antiandrogen RU 58841 may reduce androgen-dependent skin conditions in a hamster model with minimal systemic effects.

research New topical antiandrogenic formulations can stimulate hair growth in human bald scalp grafted onto mice

37 citations , January 2000 in “International Journal of Pharmaceutics”

In a study using human scalp skin grafts on SCID mice, topical flutamide and finasteride significantly improved hair growth in male-pattern baldness compared to placebo, with flutamide showing superior results to finasteride.

research Topical Antiandrogens

11 citations , January 1985 in “Archives of Dermatology”

This article discusses the complex interaction between androgens and the skin, highlighting elevated androgen levels in women with hirsutism, female-pattern hair loss, and acne, but reports no new clinical results.

research Topical antiandrogens in the treatment of male-pattern baldness

10 citations , October 1988 in “Clinics in dermatology”

This review discusses the potential of antiandrogens for androgen-induced baldness in men and women but reports no new clinical findings, emphasizing the need for further research on long-term risks and efficacy.

research Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen

9 citations , January 2017 in “Organic Process Research & Development”

This article describes the efficient synthesis of (S)-N-(2-bromo-6-methoxypyridin-4-yl)-2-hydroxy-2,4-dimethylpentanamide, a novel topical antiandrogen, with high purity and enantiomeric excess but reports no pharmacological results.

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Community Join

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community Topical Anti Androgens detailed thread

6 upvotes 1 month ago

Users discuss the effectiveness of topical anti-androgens like RU58841, Pyri (KX826), and CB for hair loss. Some report maintenance and regrowth with Pyri, while others find limited success with RU58841 and switch to combinations like finasteride and minoxidil or minoxidil and dutasteride.

community Topical Anti-Androgen users. What are y’all using currently? And what do you believe has the best chance of being approved? Or best results?

in Technology 14 upvotes 1 year ago

RU58841 is considered effective by some users, but finasteride and minoxidil are commonly used with varying dosages to manage side effects. Users report different experiences with treatments like pyrilutamide, fluridil, and RU58841, with some seeing results and others not.

community Topical anti-androgen availability in Australia

in Product 2 years ago

Availability of topical anti-androgens, especially RU58841, in Australia. Issues with customs seizures and lack of credible local sources.

community Cheap topical anti-androgens recommendations?

5 upvotes 9 months ago

The conversation is about finding affordable topical anti-androgens for hair loss. The user is currently using finasteride, dutasteride, and oral minoxidil, and is advised that additional topical treatments may not be necessary.

community How to choose between topical antiandrogen (Pyrilutamide) vs topical Alfatradiol (17α-estradiol) as an add-on treatment?

5 upvotes 10 months ago

The user is considering adding Pyrilutamide or Alfatradiol as a topical treatment for hair loss after oral Finasteride and Dutasteride became less effective. Other users suggest Pyrilutamide for its safety profile, while one user shares positive experiences with RU58841 for reducing scalp itch and improving hairline.

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Learn

7 / 29 results

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is a topical anti-androgen that degrades androgen receptors to combat hair loss.

learn Pyrilutamide

Is pyrilutamide a safer alternative to oral antiandrogens like finasteride? Pyrilutamide may be a safer topical alternative to oral antiandrogens like finasteride.
What is pyrilutamide, and how does it help with androgenic alopecia or hair loss caused by DHT? Pyrilutamide (KX-826) is an investigational topical antiandrogen designed to block DHT at the androgen receptor in the scalp rather than lower DHT in the blood. Its sponsor has announced positive Phase III top-line results in China, but none of the data are peer-reviewed and it is not approved as a medicine anywhere.
Can pyrilutamide be used by both men and women, or only in specific cases? Pyrilutamide (KX-826) is an investigational topical anti-androgen that has been trialled in both men and women, but it is not approved for hair loss anywhere; the company reports that its China Phase III trial in men met its primary endpoint, but the data come from sponsor announcements rather than peer-reviewed journals, and long-term safety is unknown.

learn Fluridil

a topical anti-androgen with less systemic involvement

learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

learn RU58841

a potent but unapproved and potentially problematic topical anti-androgen

Will I lose my hair if I stop using RU58841? (Spoiler: I might.) There is no published human trial of stopping RU58841; community members commonly report shedding within weeks to months, and androgen biology suggests miniaturization would resume once the topical anti-androgen is withdrawn.

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

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