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    Did you mean Topical Antiandrogens?
    Glossary Topical Antiandrogens

    medications applied to skin to block androgen effects locally

    Topical antiandrogens are medications applied directly to the skin to block the effects of androgens, which are hormones that can contribute to conditions like acne, hirsutism (excessive hair growth), and androgenetic alopecia (pattern hair loss). By inhibiting these hormones locally, these treatments can help manage symptoms without the systemic side effects associated with oral antiandrogens.

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    1. RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism The Journal of Steroid Biochemistry and Molecular Biology · 1994 · 49 citations
    2. New topical antiandrogenic formulations can stimulate hair growth in human bald scalp grafted onto mice International Journal of Pharmaceutics · 2000 · 37 citations
    3. Topical Antiandrogens Archives of Dermatology · 1985 · 11 citations
    4. Topical antiandrogens in the treatment of male-pattern baldness Clinics in dermatology · 1988 · 10 citations
    5. Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen Organic Process Research & Development · 2017 · 9 citations
    6. Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris American Journal of Clinical Dermatology · 2019 · 7 citations
    7. Topical antiandrogens. What use in dermatology? Archives of Dermatology · 1985 · 5 citations
    8. Clascoterone: a new topical antiandrogen agent. Prospects in Pharmaceutical Sciences · 2025
    9. Assessment of the efficacy of topical antiandrogen; spironolactone in patients with androgenetic alopecia by dermoscopy Journal of Pakistan Association of Dermatologists · 2022
    10. Cortexolone 17a-propionate: Preclinical profile of a new topical, skin selective, steroidal antiandrogen Journal of the American Academy of Dermatology · 2012
    11. Topical Minoxidil Does Not Act as an Antiandrogen in the Flank Organ of the Golden Syrian Hamster Archives of Dermatology · 1987 · 26 citations
    12. Pumpkin Seed Oil-Loaded Niosomes for Topical Application: 5α-Reductase Inhibitory, Anti-Inflammatory, and In Vivo Anti-Hair Loss Effects Pharmaceuticals · 2022 · 7 citations
    13. 0951 Breezula, a clinical stage topical anti-androgen, promotes dermal papilla inductivity and reduces IL-6 secretion in balding skin samples ex vivo Journal of Investigative Dermatology · 2025
    14. Clinical applications of antiandrogens Journal of Steroid Biochemistry · 1988 · 29 citations
    15. Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite The Journal of Steroid Biochemistry and Molecular Biology · 1994 · 16 citations
    16. The Future of Topical Therapy for Cutaneous Aging ˜The œJournal of dermatologic surgery and oncology · 1990 · 11 citations
    17. Biological Profile of Cortexolone 17a-Propionate (CB-03-01), a New Topical and Peripherally Selective Androgen Antagonist Drug Research · 2011 · 5 citations
    18. Pharmacology of Anti-androgens in the Skin Handbook of experimental pharmacology · 1989 · 1 citations
    19. Anti-androgen therapy in dermatology: a review Clinical and Experimental Dermatology · 1979 · 5 citations
    20. Anti-androgen therapy for the treatment of female pattern hair loss: a clinical review of current and emerging therapies Journal of the American Academy of Dermatology · 2025
    21. RU 58841-myristate–prodrug development for topical treatment of acne and androgenetic alopecia. PubMed · 2005 · 26 citations
    22. Antiandrogen Therapy for Female-Pattern Hair Loss NEJM Journal Watch · 2005
    23. Topical ketoconazole: a systematic review of current dermatological applications and future developments Journal of Dermatological Treatment · 2019 · 39 citations
    24. Percutaneous absorption of a new antiandrogen included in liposomes or in solution International Journal of Pharmaceutics · 1995 · 20 citations
    25. Successful topical minoxidil treatment for hair density and length in trichorhinophalangeal syndrome type 1 Pediatric Dermatology · 2024
    26. Optimal use of topical minoxidil in management of female pattern hair loss in India: an expert opinion International Journal of Research in Dermatology · 2022
    27. Role of Topical Ketoconazole in Therapeutic Hair Care Beyond Seborrhoeic Dermatitis and Dandruff JEADV Clinical Practice · 2025
    28. Melatonin and hair physiology: reasons and clinical efficacy data as a topical treatment of androgenic alopecia Medicina cutánea ibero-latino-americana · 2014
    29. Minimally Invasive Non-Surgical Therapies for Androgenetic Alopecia: A Narrative Review of Clinical Evidence for Regenerative and Locally Acting Antiandrogen Treatments Preprints.org · 2026
    30. The stimulation of hair growth in the flank organs of female hamsters by subcutaneous testosterone propionate and its inhibition by topical cyproterone acetate: dose-response studies 1983 · 15 citations