Biological Profile of Cortexolone 17a-Propionate (CB-03-01), a New Topical and Peripherally Selective Androgen Antagonist

December 2011 in “ Drug Research ”

G. Celasco, Luigi Moro, Roberta Bozzella, Patrizia Ferraboschi, Luisa Bartorelli, Cinzia Quattrocchi, F Nicoletti

cortexolone 17a-propionate CB-03-01 antiandrogenic activity androgen-dependent skin disorders topical antiandrogen progesterone flutamide finasteride cyproterone acetate glucocorticoid activity antiandrogen androgenic skin disorders Propecia

TLDR CB-03-01 is a promising skin cream for treating hormone-related skin problems without causing harmful body-wide effects.

The study investigated the antiandrogenic activity of cortexolone 17a-propionate (CB-03-01), a compound with potential for treating androgen-dependent skin disorders. CB-03-01 demonstrated strong local antiandrogenic effects in hamster skin without systemic side effects, such as affecting gonadotropin levels or causing skin irritation. It was found to be more potent than progesterone, flutamide, and finasteride, and as effective as cyproterone acetate when applied topically. However, it did not exhibit antiandrogenic or antianabolic effects when injected subcutaneously in rats, nor did it interfere with hormone secretion in parabiotic rats, except for weak glucocorticoid activity at high doses. The study concludes that CB-03-01 is a promising topical antiandrogen for skin disorders, with a need for further research to confirm its safety and effectiveness in humans. The number of animals used in the study was not specified.

View this study on thieme-connect.de →

Discuss this study in the Community →

Related Community Posts Join

6 / 6 results

community 2020 Hair and Scalp Treatments: A Clinical Guide (in Depth 350 Page Guide)

in Treatment 62 upvotes 4 years ago

Treatments for hair loss, including topical immunotherapy, regenerative treatments, laser and light-based therapies, oral supplements, intralesional steroids, and new drugs like finasteride and minoxidil.

community Clinical Trial: Clascoterone (Cortexolone 17A-Propionate)

in Research/Science 24 upvotes 7 months ago

A user is joining a clinical trial for Clascoterone, a drug approved for acne but being tested for hair loss. They previously tried finasteride with limited success and plan to share updates on their experience with the new treatment.

community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

in Treatment 90 upvotes 4 years ago

Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.

community Breezula will hit the market in 2026, Cosmo Pharmaceuticals statement!

in Product 52 upvotes 8 months ago

Breezula, a hair loss treatment, is expected to cost around $100 a month and is anticipated to be released in 2026. The effectiveness of Breezula is debated, with some suggesting it loses effectiveness over time and others arguing it maintains hair compared to baseline.

community The New, Improved CB-03-01/Setipiprant Group Buy

27 upvotes 8 years ago

The group buy for CB-03-01, a topical anti-androgen for hair loss, was postponed and refunded due to issues with the product's form and solubility. The product, also known as Breezula, is an alternative to finasteride with fewer side effects, but its official release is delayed until 2021.

community PYRILUTAMIDE KX-826 experience

in Research/Science 95 upvotes 2 years ago

A user's experience with the hair loss treatment Pyrilutamide KX-826, which has resulted in some side effects and shedding. The conversation also includes advice for baseline pictures and trying treatments for at least 6 months.

Related Research

2 / 2 results

research Biological Profile of Cortexolone 17a-Propionate (CB-03-01), a New Topical and Peripherally Selective Androgen Antagonist

5 citations, December 2011 in “Drug Research”

CB-03-01 is a promising skin cream for treating hormone-related skin problems without causing harmful body-wide effects.

research Pharmacological Options for Treatment of Hyperandrogenic Disorders

6 citations, August 2009 in “Mini-reviews in Medicinal Chemistry”

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.