Biological Profile of Cortexolone 17a-Propionate (CB-03-01), a New Topical and Peripherally Selective Androgen Antagonist

December 2011 in “ Drug Research ”

G. Celasco, Luigi Moro, Roberta Bozzella, Patrizia Ferraboschi, Luisa Bartorelli, Cinzia Quattrocchi, F Nicoletti

cortexolone 17a-propionate CB-03-01 antiandrogenic activity androgen-dependent skin disorders topical antiandrogen progesterone flutamide finasteride cyproterone acetate glucocorticoid activity antiandrogen androgenic skin disorders Propecia

TLDR CB-03-01 is a promising skin cream for treating hormone-related skin problems without causing harmful body-wide effects.

The study investigated the antiandrogenic activity of cortexolone 17a-propionate (CB-03-01), a compound with potential for treating androgen-dependent skin disorders. CB-03-01 demonstrated strong local antiandrogenic effects in hamster skin without systemic side effects, such as affecting gonadotropin levels or causing skin irritation. It was found to be more potent than progesterone, flutamide, and finasteride, and as effective as cyproterone acetate when applied topically. However, it did not exhibit antiandrogenic or antianabolic effects when injected subcutaneously in rats, nor did it interfere with hormone secretion in parabiotic rats, except for weak glucocorticoid activity at high doses. The study concludes that CB-03-01 is a promising topical antiandrogen for skin disorders, with a need for further research to confirm its safety and effectiveness in humans. The number of animals used in the study was not specified.

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