Cortexolone 17a-Propionate: Preclinical Profile of a New Topical, Skin Selective, Steroidal Antiandrogen

April 2012 in “ Journal of the American Academy of Dermatology ”

Cortexolone 17a-propionate topical antiandrogen steroidal antiandrogen clofazimine anti-inflammatory immunomodulatory agent

TLDR Clofazimine may be effective for treating ashy dermatosis.

The document reports on the case of a 46-year-old man with ashy dermatosis, a rare skin condition characterized by ash-gray patches, who was successfully treated with clofazimine. The patient showed significant improvement after six months of treatment, with no new lesions appearing. The case supports the use of clofazimine, an anti-inflammatory and immunomodulatory agent, for ashy dermatosis, which has limited therapeutic options. The number of patients in this case report is one, indicating a need for further studies with larger sample sizes to confirm the findings.

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