Cortexolone 17α-Propionate (Clascoterone) Is an Androgen Receptor Antagonist in Dermal Papilla Cells In Vitro

February 2019 in “ PubMed ”

Caridad Rosette, Niccolette Rosette, Alessandro Mazzetti, Luigi Moro, Mara Gerloni

Cortexolone 17α-propionate clascoterone androgen receptor antagonist androgenetic alopecia AGA 5α-reductase inhibitor finasteride enzalutamide IL-6 dihydrotestosterone DHT dermal papilla cells

TLDR Clascoterone may be an effective topical treatment for hair loss.

The study from 2019 investigated the effects of Cortexolone 17α-propionate (clascoterone), a novel androgen antagonist, on androgenetic alopecia (AGA), a hair disorder dependent on androgens. The research found that clascoterone inhibits androgen receptor-regulated transcription similarly to the 5α-reductase inhibitor, finasteride. Moreover, clascoterone was significantly more effective than another direct androgen receptor antagonist, enzalutamide, at inhibiting IL-6 synthesis from dihydrotestosterone-stimulated primary cultures of human scalp dermal papilla cells. These findings suggest that clascoterone could be a promising candidate for the first topical antiandrogen treatment for AGA.

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research Cortexolone 17α-Propionate (Clascoterone) Is an Androgen Receptor Antagonist in Dermal Papilla Cells In Vitro

4 citations, February 2019 in “PubMed”

Clascoterone may be an effective topical treatment for hair loss.