Guidelines of Care for the Management of Acne Vulgaris

The study provides evidence-based guidelines for managing acne vulgaris, offering 18 recommendations and 5 good practice statements. Strong recommendations include the use of benzoyl peroxide, topical retinoids, topical antibiotics, and oral doxycycline, with oral isotretinoin specifically recommended for severe cases, those causing psychosocial burden or scarring, or when standard therapies fail. Conditional recommendations are given for topical clascoterone, salicylic acid, azelaic acid, oral minocycline, sarecycline, combined oral contraceptive pills, and spironolactone. Good practice statements suggest combining topical therapies with different mechanisms, limiting systemic antibiotic use, pairing systemic antibiotics with topical treatments, and using intralesional corticosteroid injections for larger lesions. These guidelines are based on the best evidence available at the time of the review.