Safety of Dermatologic Medications in Pregnancy and Lactation

    March 2014 in “ Journal of The American Academy of Dermatology ”
    David F. Butler, Misha M. Heller, Jenny E. Murase
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    TLDR Most dermatologic medications are safe during pregnancy and breastfeeding, but some should be avoided due to potential risks.
    The document reviewed the safety of various dermatologic medications during pregnancy and lactation, providing guidance for clinicians. It concluded that topical corticosteroids, calcineurin inhibitors, biologic medications like etanercept, adalimumab, and infliximab, systemic corticosteroids, second-generation antihistamines, and certain systemic antifungals and antivirals were generally safe with minimal infant exposure. However, high potency steroids, direct nipple application, coal tar, methotrexate, cyclosporine, acitretin, dapsone, mycophenolate mofetil, rituximab, isotretinoin, griseofulvin, lindane, and malathion were advised against due to potential risks. The review emphasized monitoring and timing of breastfeeding to minimize infant exposure for certain medications.
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