Androgens Affect the Activity of Human Sebocytes in Culture Depending on the Localization of the Sebaceous Glands, and Their Effect Is Antagonized by Spironolactone

    January 1994 in “ Skin Pharmacology and Physiology ”
    Christos C. Zouboulis, Hirohiko Akamatsu, Katja Stephanek, Constantin E. Orfanos
    Studysummary This study found that testosterone and 5α-dihydrotestosterone affect human sebocytes differently depending on the skin region, with spironolactone inhibiting their proliferation and counteracting androgen effects in facial sebocytes.
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