Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review

    Alison Layton, E. Anne Eady, Heather Whitehouse, J.Q. Del Rosso, Zbys Fedorowicz, Esther J van Zuuren
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    TLDR Oral spironolactone's effectiveness for adult female acne is not well-supported by strong evidence.
    The systematic review of randomized controlled trials (RCTs) and case series on oral spironolactone for acne vulgaris in adult females found that the evidence supporting its use at typical doses (≤100 mg/day) in clinical practice was of limited quality.
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