Treatment of Hirsutism and Acne in Women With Two Combinations of Cyproterone Acetate and Ethinylestradiol

    December 1976 in “ PubMed ”
    C Cremoncini, E Vignati, A. Libroia
    From the encyclopedia
    Cyproterone →

    a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

    Ethinylestradiol →
    Studysummary This study found that the combination of cyproterone acetate and ethinyl estradiol improved hirsutism and acne in women, with SH 8.1041 showing significant results and both treatments being generally well-tolerated.
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    The study involved 175 women with hirsutism and acne, treated with two combinations of cyproterone acetate and ethinylestradiol (SH 8.1041 and SH B209AB). SH 8.1041 showed significant improvement in most patients, while SH B209AB was used for maintenance therapy and initial treatment for milder acne. Hirsutism reduction was noticeable after the fourth cycle, and acne improved after the first month. Both treatments were well-tolerated, though some patients on SH 8.1041 experienced mild side effects like transient frigidity, depression, breast discomfort, and nausea.
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