TLDR The hormonal contraceptive combination effectively reduces androgen excess and improves PCOS symptoms like acne, hair loss, and menstrual issues.
The study investigated the effects of a combination of ethinylestradiol and cyproterone acetate on symptoms of polycystic ovarian syndrome (PCOS) in women, focusing on hyperandrogenic symptoms such as acne, hirsutism, and alopecia. Conducted in a private gynecological clinic, the study included women diagnosed with PCOS according to the Rotterdam criteria. Results showed significant improvement in acne, with 93.75% of patients showing improvement after 12 months. Alopecia improved in 83.33% of patients after more than 6 cycles, while 72.72% of patients with hirsutism showed improvement after 9-12 months. Menstrual irregularities and dysmenorrhea also improved, with good tolerance and satisfaction reported by most patients. The study concluded that the hormonal contraceptive combination effectively reduced androgen excess, the primary defect in PCOS, and improved related symptoms.
11 citations,
April 2017 in “The European Journal of Contraception & Reproductive Health Care” Cyproterone acetate with ethinyl estradiol is effective for treating skin symptoms related to high androgen levels, like in PCOS.
1514 citations,
December 2011 in “Fertility and sterility” Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.
26 citations,
February 2011 in “Anais Brasileiros De Dermatologia” Polycystic Ovary Syndrome can cause hair loss and skin issues, and early treatment is important for preventing complications.
67 citations,
February 2010 in “Acta Obstetricia et Gynecologica Scandinavica” Hirsutism is a strong sign of high male hormones and metabolic problems in women with PCOS, but acne and hair loss are not.
947 citations,
February 2004 in “The Journal of Clinical Endocrinology and Metabolism” Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.
84 citations,
November 2003 in “European journal of endocrinology” Women with androgenic alopecia are more likely to have polycystic ovaries and higher androgen levels, which may indicate PCOS.
49 citations,
April 1997 in “Human reproduction” Hormone therapy for excessive hair growth is as good with GnRHa as with high-dose CPA, but GnRHa has longer-lasting results.
8 citations,
April 1991 in “European journal of endocrinology” 3α-AdiolG is a good marker for androgen activity in women with excessive hair growth and decreases with anti-androgen treatment.
8 citations,
November 1978 in “British journal of dermatology/British journal of dermatology, Supplement” Cyproterone acetate can effectively treat idiopathic hirsutism, but ethinyl oestradiol and lynoestrenol may not always reduce hair growth.
