Comparison of Flutamide and Spironolactone in the Treatment of Hirsutism: A Randomized Controlled Trial

    February 1994 in “ Fertility and Sterility ”
    Lionel Cusan, André Dupont, José‐Luis Gomez, Roland R. Tremblay, Fernand Labrie
    Image of study
    TLDR Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.
    In a study from 30 years ago involving 53 premenopausal women with moderate to severe hirsutism, flutamide was found to be significantly more effective than spironolactone when used in combination with a triphasic oral contraceptive pill. Over a treatment period of 9 months and a 6-month follow-up, flutamide achieved a 50% reduction in hirsutism scores at 6 months and an 80% decrease in total acne, seborrhea, and hair loss score at 3 months, while spironolactone only achieved a 30% reduction in hirsutism and a 50% reduction in the other symptoms, with no significant effect on hair loss. Flutamide also had a lower rate of adverse side effects, with only one patient discontinuing due to dry skin, compared to four discontinuations in the spironolactone group due to various side effects. The study concluded that flutamide is a more effective and preferable treatment for hirsutism and related androgen-dependent symptoms than spironolactone.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 21 results

      community Any balding females? I need advice with coping :(

       16 upvotes 8 years ago
      A 27-year-old woman is struggling with hair loss, feeling self-conscious and seeking advice on coping. She mentions trying Minoxidil but is hesitant due to scalp issues and is looking for ways to regain confidence.

      community Monthly Reminder.

       8 upvotes 6 years ago
      Various treatments for male pattern baldness including Minoxidil, Finasteride/Dutasteride, hair systems, and oral anti-androgens such as Spironolactone and Flutamide. It also mentions dermarolling as a possible treatment in conjunction with minoxidil.

      community Are these all the anti androgen products?

      in Treatment  6 upvotes 1 year ago
      The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

      community Hair Remedies that Don't Work for Anybody Seeking Hair Regrowth

      in Treatment  7 upvotes 4 years ago
      Hair loss treatments discussed include minoxidil, finasteride, and RU58841. Salon products and supplements generally don't work for hair regrowth unless there's a severe nutritional deficiency, while hormonal treatments like estrogen and spironolactone can be effective.

    Related Research

    3 / 3 results