Treatment of Hirsutism with the Pure Antiandrogen Flutamide

September 1990 in “ Journal of the American Academy of Dermatology ”

Léonello Cusan, André Dupont, Alain Bélanger, Roland R. Tremblay, Gilles Manhès, Fernand Labrie

flutamide antiandrogen oral contraceptive spironolactone dexamethasone hirsutism seborrhea acne hair loss luteinizing hormone progesterone estradiol sex hormone-binding globulin Ortho 1/35

From the encyclopedia

Spironolactone →

powerful topical and oral anti-androgen used mostly by women

Estradiol →

an estrogen promoting hair regrowth more commonly used in women

Studysummary This study found that combining flutamide with an oral contraceptive significantly reduced hirsutism, acne, and seborrhea in patients after seven months, without significant side effects.

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Research cited in this study

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research Effects of Flutamide, a Pure Antiandrogen, on Endocrine Parameters in the Adult Female Rat

8 citations , January 1987 in “Gynecological Endocrinology”

This study found that treatment with the pure antiandrogen Flutamide did not affect the estrous cycle or plasma levels of most hormones in female rats, supporting its potential use for treating hirsutism, acne, and alopecia in women.

research Cyproterone Acetate as Initial Treatment and Maintenance Therapy for Hirsutism

18 citations , August 1985 in “European journal of endocrinology”

This study found that high-dose cyproterone acetate was effective for treating hirsutism, but 33% of patients felt their condition worsened on low-dose maintenance therapy, despite no significant change in objective measures of hair growth.

research Female Hirsutism: Pathophysiological Considerations and Therapeutic Implications

53 citations , October 1984 in “Endocrine reviews”

This review highlights that idiopathic hirsutism is characterized by local hyperandrogenization affecting hair growth, without other signs of hyperandrogenism, and shows no new results; racial differences in prevalence are noted but not in androgenic steroids.

research Treatment of Hirsutism and Acne in Women With Two Combinations of Cyproterone Acetate and Ethinylestradiol

42 citations , December 1976 in “PubMed”

This study found that the combination of cyproterone acetate and ethinyl estradiol improved hirsutism and acne in women, with SH 8.1041 showing significant results and both treatments being generally well-tolerated.

research Use of Cyproterone Acetate in the Treatment of Acne, Hirsutism, and Virilism

232 citations , June 1975 in “Journal of Steroid Biochemistry”

In this study, a treatment regimen combining cyproterone acetate and ethinyl estradiol significantly improved acne and seborrhoea in most women after three months, but had varied effects on hirsutism and alopecia.