Treat Androgenetic Alopecia With Antiandrogens And Other Pharmacological And Non-Pharmacological Interventions

April 2017 in “ Drugs & Therapy Perspectives ”

Adis Medical Writers

androgenetic alopecia antiandrogens finasteride dutasteride spironolactone cyproterone acetate minoxidil PGF₂ analogues PGD₂ selective antagonists ketoconazole AGA Propecia Rogaine

TLDR Use antiandrogens and other treatments for hair loss.

The document discusses various pharmacological and non-pharmacological interventions for treating androgenetic alopecia (AGA) in both men and women. The main first-line treatments for male AGA are oral and topical finasteride and dutasteride, while dutasteride, spironolactone, and cyproterone acetate are used for female AGA. Minoxidil is the only topical agent approved for both male and female AGA. Other treatments such as PGF₂ analogues, PGD₂ selective antagonists, and ketoconazole are also discussed. The document also highlights the potential side effects and limitations of each treatment.

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research Androgenetic Alopecia: An Update Of Treatment Options

110 citations, August 2016 in “Drugs”

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia

research Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia

42 citations, December 2015 in “International Journal of Clinical Pharmacology and Therapeutics”

The 0.25% finasteride solution, when applied once a day, effectively reduces scalp DHT, potentially minimizing sexual side-effects linked to a systemic DHT reduction.

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Blocking JAK-STAT signaling can lead to hair growth.

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Latanoprost may cause scalp inflammation and delayed healing.

A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers

research A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers

50 citations, October 2014 in “International Journal of Clinical Pharmacology and Therapeutics”

New finasteride solution effectively reduces baldness-causing hormone, potentially with fewer side effects.

The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride

research The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride

66 citations, June 2013 in “Journal of Dermatological Treatment”

Finasteride and dutasteride effectively treat hair loss, but may cause side effects like sexual dysfunction and depression.

research The Prostamide-Related Glaucoma Therapy, Bimatoprost, Offers a Novel Approach for Treating Scalp Alopecias

53 citations, October 2012 in “The FASEB Journal”

Bimatoprost, a glaucoma medication, may also help treat hair loss.

research Minoxidil Use in Dermatology, Side Effects, and Recent Patents

152 citations, April 2012 in “Recent Patents on Inflammation & Allergy Drug Discovery”

Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations, March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

research Global Photographic Assessment of Men Aged 18 to 60 Years with Male Pattern Hair Loss Receiving Finasteride 1 mg or Placebo

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Finasteride significantly improves hair growth but may cause sexual side effects.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

198 citations, October 2011 in “Journal der Deutschen Dermatologischen Gesellschaft”

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

research A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

81 citations, August 2011 in “Journal of The American Academy of Dermatology”

Latanoprost 0.1% may effectively treat hair loss.

research The Effect of a 1550 Nm Fractional Erbium-Glass Laser in Female Pattern Hair Loss

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Laser treatment increases hair density and thickness safely in women with hair loss.

research Oral Finasteride Improved the Quality of Life of Androgenetic Alopecia Patients

23 citations, August 2011 in “Journal of Dermatology”

Finasteride helps hair loss patients' quality of life.

research Treatment of Female Pattern Hair Loss with the Androgen Receptor Antagonist Flutamide

30 citations, March 2011 in “Australasian Journal of Dermatology”

Flutamide improves female hair loss when other treatments fail, but may cause liver toxicity.

research Fractional Photothermolysis Laser Treatment of Male Pattern Hair Loss

50 citations, December 2010 in “Dermatologic Surgery”

Laser treatment can stimulate hair growth for male pattern hair loss.

research Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia

152 citations, October 2010 in “Archives of Dermatology”

Finasteride helps hair growth but may cause sexual side effects.

research Comparing the Therapeutic Effects of Finasteride Gel and Tablet in Treatment of Androgenetic Alopecia

57 citations, January 2009 in “Indian Journal of Dermatology, Venereology and Leprology”

Finasteride gel is slightly more effective than the tablet for treating hair loss.

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

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Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

research A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss

219 citations, March 2004 in “Journal of The American Academy of Dermatology”

5% and 2% minoxidil solutions effectively promote hair growth and reduce hair loss, with 5% being slightly more effective but having more side effects.

research Ketoconazole as an Adjunct to Finasteride in the Treatment of Androgenetic Alopecia in Men

28 citations, December 2003 in “Medical Hypotheses”

Ketoconazole shampoo with finasteride improves hair density in men with hair loss.

research Hypertrichosis in Females Applying Minoxidil Topical Solution and in Normal Controls

63 citations, May 2003 in “Journal of The European Academy of Dermatology and Venereology”

Minoxidil use increases facial hair growth in females, more in older users.

A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations, August 2002 in “Journal of The American Academy of Dermatology”

5% minoxidil works better for hair growth and density, with minor irritation.

research Effects of Minoxidil 2% vs. Cyproterone Acetate Treatment on Female Androgenetic Alopecia: A Controlled, 12-Month Randomized Trial

149 citations, June 2002 in “British Journal of Dermatology”

Minoxidil works better for female hair loss, but cyproterone reduces scalp oiliness and causes menstrual issues.

Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

research Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

81 citations, February 1997 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by activating PGHS-1.

research Clinical Pharmacokinetics and Pharmacodynamics of Finasteride

93 citations, January 1996 in “Clinical Pharmacokinectics”

Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

research Selective Inhibition by Minoxidil of Prostacyclin Production by Cells in Culture

23 citations, March 1988 in “Biochemical Pharmacology”

Minoxidil stops cells from making prostacyclin, which may help with hair growth. More research is needed.

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