Erosive Pustular Dermatosis of the Scalp Following Topical Latanoprost for Androgenetic Alopecia

January 2015 in “ Dermatologic Therapy ”

Mario Vaccaro, Olga Barbuzza, Francesco Borgia, Salvatore Cannavò

erosive pustular dermatosis of the scalp topical latanoprost androgenetic alopecia scarring alopecia prostaglandin analogs EPDS latanoprost pattern baldness

Studysummary This letter discusses a case of erosive pustular dermatosis of the scalp linked to topical latanoprost use for androgenetic alopecia, but reports no clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The article reports a case of a 61-year-old woman who developed erosive pustular dermatosis of the scalp (EPDS) after using topical latanoprost for androgenetic alopecia. EPDS is an inflammatory chronic disease that leads to scarring alopecia. Although trauma is known to precipitate this condition, topical latanoprost has not previously been reported as a triggering factor. The authors suggest that EPDS should be considered in any subject developing a chronic inflammatory response or delayed healing after latanoprost treatment. More research is needed to determine the efficacy and safety of latanoprost or other prostaglandin analogs for hair growth.

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Research cited in this study

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A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

research A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

81 citations , August 2011 in “Journal of The American Academy of Dermatology”

In this study, latanoprost significantly increased hair density in young men with mild androgenetic alopecia after 24 weeks, suggesting it may stimulate hair follicle activity and treat hair loss.

research Erosive Pustular Dermatosis of the Scalp Following Topical Methylaminolaevulinate Photodynamic Therapy

52 citations , February 2009 in “Journal of the American Academy of Dermatology”

This case study identified erosive pustular dermatosis of the scalp following methylaminolaevulinate photodynamic therapy, noting improvement with steroid treatment and partial resolution of atrophy after three months.