Selective Inhibition by Minoxidil of Prostacyclin Production by Cells in Culture

March 1988 in “ Biochemical Pharmacology ”

Joseph C. Kvedar, Howard P. Baden, Lawrence Levine

minoxidil prostacyclin hair growth keratinocytes Rogaine

TLDR Minoxidil stops cells from making prostacyclin, which may help with hair growth. More research is needed.

Minoxidil selectively inhibits the production of prostacyclin in cultured cells, which may be linked to its ability to promote hair growth. The study found that minoxidil can block the production of prostacyclin by certain cells in culture, but not in newborn rat keratinocytes. The mechanism behind this inhibition is still unknown, and further research is needed to determine the implications of this for hypertension treatment and other conditions related to prostacyclin and thromboxane B2.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

research In Vitro Suppression of Human Lymphocyte Activity by Minoxidil

17 citations, January 1985 in “International Journal of Dermatology”

Minoxidil may help hair growth by stopping immune system attacks on hair follicles.

research Alopecia Areata: Pathogenesis And Treatment

122 citations, November 1984 in “Journal of the American Academy of Dermatology”

No single treatment is consistently effective for alopecia areata, and more research is needed.

research Alopecia Areata Treated With Topical Minoxidil

78 citations, April 1984 in “Archives of Dermatology”

Minoxidil can help regrow hair in alopecia areata patients.

research Direct Effects of Minoxidil on Epidermal Cells in Culture

63 citations, January 1984 in “Journal of Investigative Dermatology”

Minoxidil promotes hair growth by increasing cell division and DNA synthesis.

research Effect of Minoxidil on Cultured Keratinocytes

72 citations, December 1983 in “Journal of Investigative Dermatology”

Minoxidil helps hair cells live longer and grow longer.

research Topical Minoxidil in Alopecia Areata

56 citations, August 1981 in “Journal of The American Academy of Dermatology”

Minoxidil helps hair regrowth in alopecia areata safely.

research Hypertrichosis Due to Minoxidil

73 citations, November 1979 in “British Journal of Dermatology”

Minoxidil can cause excessive hair growth.

research Minoxidil for Severe Hypertension After Failure of Other Hypotensive Drugs

86 citations, September 1977 in “BMJ”

Minoxidil effectively controls blood pressure in severe cases, but has serious side effects and causes hair growth in women.

research Minoxidil in Resistant Hypertension

102 citations, September 1977 in “The Lancet”

Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.

research Minoxidil-Induced Hypertrichosis: Treatment with Calcium Thioglycolate Depilatory Agent

46 citations, April 1977 in “Southern Medical Journal”

Minoxidil causes excessive hair growth, but depilatory agent removes it safely and effectively.

Related Research

1 / 1 results

research Selective Inhibition by Minoxidil of Prostacyclin Production by Cells in Culture

23 citations, March 1988 in “Biochemical Pharmacology”

Minoxidil stops cells from making prostacyclin, which may help with hair growth. More research is needed.