Selective Inhibition by Minoxidil of Prostacyclin Production by Cells in Culture

    March 1988 in “ Biochemical Pharmacology ”
    Joseph C. Kvedar, Howard P. Baden, Lawrence Levine
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    TLDR Minoxidil stops cells from making prostacyclin, which may help with hair growth. More research is needed.
    Minoxidil selectively inhibits the production of prostacyclin in cultured cells, which may be linked to its ability to promote hair growth. The study found that minoxidil can block the production of prostacyclin by certain cells in culture, but not in newborn rat keratinocytes. The mechanism behind this inhibition is still unknown, and further research is needed to determine the implications of this for hypertension treatment and other conditions related to prostacyclin and thromboxane B2.
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