Effect of Minoxidil on Cultured Keratinocytes

December 1983 in “ Journal of Investigative Dermatology ”

Howard P. Baden, Joseph Kubilus

minoxidil keratinocytes epidermal growth factor hair matrix cells senescence Rogaine EGF

TLDR Minoxidil helps hair cells live longer and grow longer.

The study investigated the effect of minoxidil on cultured keratinocytes and found that it prolonged the survival of cells and delayed senescence, similar to epidermal growth factor. The researchers concluded that minoxidil may stimulate hair matrix cells directly and slow the senescence of keratinocytes, which could contribute to the increase in hair length produced by minoxidil. Further studies are needed to determine the mechanism of action of minoxidil.

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Research cited in this study

6 / 6 results

research Topical Minoxidil in Alopecia Areata

56 citations, August 1981 in “Journal of The American Academy of Dermatology”

Minoxidil helps hair regrowth in alopecia areata safely.

research Reversal of Baldness in Patient Receiving Minoxidil for Hypertension

95 citations, December 1980 in “The New England Journal of Medicine”

Minoxidil helped bald patient regrow hair.

research Hypertrichosis Due to Minoxidil

73 citations, November 1979 in “British Journal of Dermatology”

Minoxidil can cause excessive hair growth.

research Minoxidil in Resistant Hypertension

102 citations, September 1977 in “The Lancet”

Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.

research Minoxidil for Severe Hypertension After Failure of Other Hypotensive Drugs

86 citations, September 1977 in “BMJ”

Minoxidil effectively controls blood pressure in severe cases, but has serious side effects and causes hair growth in women.

research Minoxidil-Induced Hypertrichosis: Treatment with Calcium Thioglycolate Depilatory Agent

46 citations, April 1977 in “Southern Medical Journal”

Minoxidil causes excessive hair growth, but depilatory agent removes it safely and effectively.

Related Research

5 / 5 results

research The Efficacy of Topical Minoxidil for Non-Scarring Alopecia: A Systematic Review

1 citations, February 2019 in “PubMed”

Minoxidil is effective in treating various types of hair loss and can improve quality of life, with combination therapies showing increased effectiveness.

research Male Androgenetic Alopecia Treated with Microneedling Alone or Associated with Injectable Minoxidil by Microinfusion of Drugs into the Skin

5 citations, January 2016 in “Surgical and Cosmetic Dermatology”

research Topical Minoxidil for Hair Growth in Alopecia Areata and Androgenetica

24 citations, February 1987 in “Drugs”

Minoxidil promotes hair regrowth, but more research needed for effectiveness and response factors.

research Alopecia Areata Treated With Topical Minoxidil

78 citations, April 1984 in “Archives of Dermatology”

Minoxidil can help regrow hair in alopecia areata patients.

research Topical Minoxidil in the Treatment of Alopecia Areata

80 citations, October 1983 in “BMJ”

Minoxidil helps hair regrowth in alopecia patients, with 16 having good results and no side effects.

Effect of Minoxidil on Cultured Keratinocytes

Research cited in this study

research Topical Minoxidil in Alopecia Areata

research Reversal of Baldness in Patient Receiving Minoxidil for Hypertension

research Hypertrichosis Due to Minoxidil

research Minoxidil in Resistant Hypertension

research Minoxidil for Severe Hypertension After Failure of Other Hypotensive Drugs

research Minoxidil-Induced Hypertrichosis: Treatment with Calcium Thioglycolate Depilatory Agent

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