Effects of Minoxidil 2% vs. Cyproterone Acetate Treatment on Female Androgenetic Alopecia: A Controlled, 12-Month Randomized Trial

    Patrick Vexiau, C Chaspoux, Philippe Boudou, Jean Fiet, C Jouanique, N. Hardy, Pascal Reygagne
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    TLDR Minoxidil works better for female hair loss, but cyproterone reduces scalp oiliness and causes menstrual issues.
    This study from 20 years ago compared the effectiveness of minoxidil 2% and cyproterone acetate treatments on female androgenetic alopecia. The study involved 66 patients who were randomized into two groups. The results showed that both treatments led to a significant increase in the total number of hairs, but the minoxidil group had a stronger response. Patients on cyproterone acetate had a greater reduction in scalp seborrhoea, but also experienced more menstrual cycle irregularities. Overall, the study suggests that minoxidil may be a more effective treatment for female androgenetic alopecia, especially when alopecia is the only symptom and there are no signs of hyperandrogenism.
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