Hypertrichosis in Females Applying Minoxidil Topical Solution and in Normal Controls

    Rodney P.R. Dawber, J Rundegren
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    TLDR Minoxidil use increases facial hair growth in females, more in older users.
    The article examines the occurrence of hypertrichosis in females using minoxidil topical solution (MTS) for androgenetic alopecia (AGA). The study found that hypertrichosis/facial hair occurred more frequently in females who used MTS, with a dose-related pattern of response. The occurrence of hypertrichosis was slightly higher in older females relative to younger females for the 5% MTS group. The study also analyzed spontaneously reported adverse events of facial hair growth and hypertrichosis, which were estimated by the clinical investigator to be drug-related in a dose-dependent manner. The occurrence of hypertrichosis/facial hair reported by females was approximately 0.5%, which was considerably lower than that found in the adverse event reports in the clinical trials.
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