Clascoterone: First Approval

October 2020 in “ Drugs ”

Sohita Dhillon

clascoterone androgen receptor inhibitor androgen-dependent skin disorders acne vulgaris androgenetic alopecia dihydrotestosterone androgen receptors sebaceous glands hair follicles Winlevi DHT

TLDR Clascoterone cream was approved in the USA for treating acne in people aged 12 and older.

Clascoterone (Winlevi®) was an androgen receptor inhibitor developed by Cassiopea for treating androgen-dependent skin disorders like acne vulgaris and androgenetic alopecia. In August 2020, clascoterone cream 1% was approved in the USA for treating acne vulgaris in patients aged 12 and older. The drug was believed to work by competing with dihydrotestosterone for binding to androgen receptors in sebaceous glands and hair follicles, reducing the signaling necessary for acne development. Clinical studies for a higher concentration solution of clascoterone for androgenetic alopecia were ongoing in Germany and the USA.

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Research cited in this study

3 / 3 results

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