Search

for
Search:

Glossary Nonsteroidal Antiandrogens

medications that block male hormones without activating their receptors

Nonsteroidal Antiandrogens (NSAA) are medications that block the action of androgens (male hormones like testosterone) by binding to androgen receptors without activating them. They are commonly used in the treatment of conditions like prostate cancer and androgenic alopecia (hair loss) by preventing androgens from stimulating the growth of cancer cells or hair follicles.

Related Terms

Research

5 / 1000+ results

research Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide

88 citations , February 2008 in “Journal of Medicinal Chemistry”

Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.

research Histological and immunohistochemical examination of the effect of the nonsteroidal antiandrogen {flutamide} on some organs of the male reproductive system in albino rats

September 2012 in “The Egyptian Journal of Histology”

In this study, flutamide at therapeutic doses caused significant histological changes in the testes and epididymis of adult albino rats, reducing androgen receptor immunoreactivity and increasing estrogen receptor immunoreactivity.

research Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite

16 citations , October 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

research A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice

10 citations , November 1997 in “British Journal of Dermatology”

This study found that the non-steroidal antiandrogen RU58841 increased hair growth rates and promoted hair cycle initiation in balding human scalp grafts on testosterone-conditioned nude mice, indicating a positive effect on hair growth.

research A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice

9 citations , November 1997 in “British Journal of Dermatology”

View more "nonsteroidal antiandrogens" in research →

Community Join

5 / 41 results

community Has anyone find a way to stop/limit ru58841 to go systematic ?

in Finasteride/Dutasteride 4 upvotes 1 year ago

RU58841 is a strong non-steroidal antiandrogen for hair loss but may cause cardiovascular issues in some users. Alternatives like Pyrilutamide and Breezula are suggested due to better safety profiles and lower systemic risks.

community Severe dry eye: finasteride vs dutasteride

8 upvotes 5 years ago

Woman uses antiandrogens for hair thinning prevention, experiences severe dry eye with finasteride. Asks if dutasteride could be better despite potential for worse dry eye.

community Methods Of Staying Safe On Ru58841 - My 2 Cents

in Research/Science 21 upvotes 1 year ago

RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.

community Fluridil (Eucapil) seems like a great option?

4 upvotes 9 months ago

The user stopped using finasteride due to side effects and is considering Fluridil (Eucapil) as an alternative for hair loss treatment. They are exploring other options like RU58841 and are interested in the experiences of others with Fluridil, noting its good safety profile despite the cost.

community 2 years on dut (.5mg three times per week) 1 and a half on RU 5% (once a day)

266 upvotes 1 year ago

The user experienced significant hair regrowth using dutasteride (0.5 mg three times a week) and RU58841 (5% once a day), with no side effects reported from RU58841. They are considering increasing the RU58841 dose or adding minoxidil for further improvement.

View more "nonsteroidal antiandrogens" in community →

Learn

3 / 3 results

learn Bicalutamide

Nonsteroidal anti-androgen, originally a prostate cancer drug

learn Fluridil

Topical anti-androgen sold as a cosmetic lotion

learn Pyrilutamide

Experimental topical anti-androgen, also known as KX-826

Experts

— no results

Try a deeper search in experts →

Clinics

— no results

Try a deeper search in clinics →