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    Glossary Nonsteroidal Antiandrogens

    medications that block male hormones without activating their receptors

    Nonsteroidal Antiandrogens (NSAA) are medications that block the action of androgens (male hormones like testosterone) by binding to androgen receptors without activating them. They are commonly used in the treatment of conditions like prostate cancer and androgenic alopecia (hair loss) by preventing androgens from stimulating the growth of cancer cells or hair follicles.

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    1. Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide Journal of Medicinal Chemistry · 2008 · 88 citations
    2. Histological and immunohistochemical examination of the effect of the nonsteroidal antiandrogen {flutamide} on some organs of the male reproductive system in albino rats The Egyptian Journal of Histology · 2012
    3. Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite The Journal of Steroid Biochemistry and Molecular Biology · 1994 · 16 citations
    4. A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice British Journal of Dermatology · 1997 · 10 citations
    5. A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice British Journal of Dermatology · 1997 · 9 citations
    6. Pharmacology of antiandrogens Journal of Steroid Biochemistry · 1986 · 97 citations
    7. Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors Current Medicinal Chemistry · 2005 · 20 citations
    8. Female Antiandrogens Elsevier eBooks · 2017 · 1 citations
    9. The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function American Journal of Pathology · 2003 · 72 citations
    10. Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, <i>InVitro</i>, and <i>In Silico</i> Studies OPAL (Open@LaTrobe) (La Trobe University) · 2025
    11. Clinical applications of antiandrogens Journal of Steroid Biochemistry · 1988 · 29 citations
    12. Antiandrogens CRC Press eBooks · 2022
    13. The antiandrogenic effect of finasteride against a mutant androgen receptor Cancer Biology & Therapy · 2011 · 20 citations
    14. Development of radioiodinated nonsteroidal androgen receptor ligands for spect imaging of prostate cancer Journal of Labelled Compounds and Radiopharmaceuticals · 2001 · 1 citations
    15. Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships Current Medicinal Chemistry · 2000 · 204 citations
    16. Non polycystic ovary syndrome–related endocrine disorders associated with hirsutism European Journal of Clinical Investigation · 2011 · 39 citations
    17. Proxalutamide Improves Inflammatory, Immunologic, and Thrombogenic Markers in Mild-to-Moderate COVID-19 Males and Females: an Exploratory Analysis of a Randomized, Double-Blinded, Placebo-Controlled Trial Early Antiandrogen Therapy (EAT) with Proxalutamide (The EAT-Proxa Biochemical AndroCoV-Trial) medRxiv (Cold Spring Harbor Laboratory) · 2021 · 5 citations
    18. Oral Contraceptives as Anti-Androgenic Treatment of Acne 2002 · 16 citations
    19. New Methods of Endocrine Management of Prostatic Cancer 1987 · 67 citations
    20. Recent discoveries and developments of androgen receptor based therapy for prostate cancer MedChemComm · 2015 · 17 citations
    21. Efficacy and safety of bicalutamide in female hair loss: a review of the literature JAAD reviews. · 2025
    22. Investigation Into the Metabolism and Elimination Behavior of RU 58841, and Its Influence on the Steroid Profile in Humans Biomedical Chromatography · 2026
    23. Bicalutamide in Dermatology: A Narrative Review Indian Dermatology Online Journal · 2024 · 1 citations
    24. Bioavailability File: Bicalutamide Fabad Journal of Pharmaceutical Sciences · 2025
    25. Structural perspectives on the androgen receptor, the elusive shape-shifter Steroids · 2024
    26. Diagnostik und Therapie der kutanen Androgenisierung im klimakterischen Übergang sowie in der Peri- und Postmenopause: Hirsutismus und Alopezie Journal für Kardiologie (Krause & Pachernegg GmbH) · 2012 · 2 citations
    27. Targets to treat androgen excess in polycystic ovary syndrome Expert Opinion on Therapeutic Targets · 2015 · 14 citations
    28. Proxalutamide Reduction of Mortality Rate in Hospitalized COVID-19 Patients Depends on Treatment Duration – an Exploratory Analysis of the Proxa-Rescue AndroCoV Trial bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 5 citations
    29. Flutamide 2025
    30. Distinctive features of steroid hormone metabolism in female patients with androgenic alopecia Vestnik dermatologii i venerologii · 2013