research The effect of the antiandrogen IIα-hydroxyprogesterone on sebum production and cholesterol concentration of sebum
The antiandrogen 11α-hydroxyprogesterone effectively reduces skin oil and cholesterol when applied to the skin.
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5 / 1000+ results research Therapeutic effect of finasteride through its antiandrogenic and antioxidant role in a propionic acid-induced autism model: Demonstrated by behavioral tests, histological findings and MR spectroscopy
In this animal study, finasteride significantly improved autism-like symptoms in rats by reversing biochemical markers and enhancing behaviors, potentially due to its antioxidant and anti-androgen effects.
research Androgenic and anti-androgenic effects of progesterone derivatives with different halogens as substituents at the C-6 position
This study found that compound 10 inhibited testosterone conversion to DHT in hamster flank organs and seminal vesicles, whereas compound 11's inhibitory effect varied with dose, linked to halogen electronegativity differences.
research The Effect of Anti-Androgens on the Response of Rat Preputial Glands to Testosterone*
This study reports that new compounds with anti-androgenic effects were found to counteract testosterone in animals without significant estrogenic activity, indicating potential for managing androgen-related conditions.
research The Effect of Mesenchymal Stem Cells Derived-Conditioned Media in Combination with Oral Anti-Androgenic Drugs on Male Pattern Baldness: An Animal Study.
In this study using animal models, umbilical cord stem cell conditioned media combined with oral anti-androgens improved hair regeneration in androgenetic alopecia, enhancing hair follicle cycles and reducing inflammation, suggesting potential as a promising therapy.
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5 / 299 resultscommunity Minoxidil is NOT an Anti-androgen. No.
Minoxidil is not an anti-androgen; it is a growth stimulator and does not lower DHT like finasteride or dutasteride. Minoxidil can cause side effects like facial swelling and anxiety due to its vasodilator properties.
community Which is safest carrier for topical antiandrogens (finasteride/kx-826/ru/dutasteride)
The conversation is about finding a safe carrier for topical antiandrogens like finasteride, kx-826, RU58841, and dutasteride to minimize systemic absorption and side effects. The user experiences side effects from these treatments and is seeking advice on carriers that reduce these effects.
community Finastride vs Spironolactone, what's more effective? Using together help?
Using both finasteride and spironolactone together is more effective for hair loss in females, as they have different mechanisms and complement each other. It's important to avoid these medications during pregnancy and choose birth control with anti-androgenic activity.
community How to choose between topical antiandrogen (Pyrilutamide) vs topical Alfatradiol (17α-estradiol) as an add-on treatment?
The user is considering adding Pyrilutamide or Alfatradiol as a topical treatment for hair loss after oral Finasteride and Dutasteride became less effective. Other users suggest Pyrilutamide for its safety profile, while one user shares positive experiences with RU58841 for reducing scalp itch and improving hairline.
community Is shedding a good sign for antiandrogens?
Shedding may indicate potential regrowth when using KX-826, similar to Minoxidil and finasteride. Users report improved hair quality and minor side effects like slight headaches.
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8 / 12 results- Is pyrilutamide a safer alternative to oral antiandrogens like finasteride? Pyrilutamide may be a safer topical alternative to oral antiandrogens like finasteride.
- Can bicalutamide stop DHT from shrinking your hair follicles? Bicalutamide blocks androgens at the receptor rather than lowering DHT, and some dermatologists prescribe it off-label for women with pattern hair loss. The published evidence is retrospective case series and one small pilot study, with no randomized trial; it is a prescription drug that requires liver monitoring and is contraindicated in pregnancy.
- Dutasteride side effects: what the label and studies actually report The Avodart label reports impotence in 4.7% and decreased libido in 3.0% of men in the first six months (1.7% and 1.4% on placebo), with new reports falling after month six; those figures come from BPH trials in older men, and the hair-loss trials in younger men run only six months. The label and studies also flag a PSA drop of about half, a small rise in high-grade prostate cancer in one trial, an observational link to depression, and sexual effects that the label says may persist after stopping.
- Does metformin help control DHT levels that trigger androgenic alopecia? Metformin has been shown to lower circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.
learn Minoxidil
An essential vasodilator with some anti-androgenic effects
learn Lavender
plant and natural oil with antimicrobial and some anti-androgenic effects
learn Ketoconazole
antifungal with some anti-androgenic benefits, often used as a shampoo
learn Spironolactone
powerful topical and oral anti-androgen used mostly by women
learn Pyrilutamide
highly targeted anti-androgen that might have minimal systemic effects
learn Bicalutamide
learn Dutasteride
learn Metformin
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