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    Steroidal 5α-Reductase and 17α-Hydroxylase/17,20-Lyase (CYP17) Inhibitors Useful in the Treatment of Prostatic Diseases

    Jorge A. R. Salvador, Rui M. A. Pinto, Samuel Silvestre
    Studysummary This review examines the role of steroidal inhibitors in treating prostatic diseases but presents no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 27

    1. Synthesis and Biological Evaluation of Novel Unsaturated Carboxysteroids as Human 5α-Reductase Inhibitors: A Legitimate Approach European journal of medicinal chemistry · 2012
    2. Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-Diene or 4,6-Diene 20-Ones and 4-Azasteroid 20-Oximes Molecules · 2011
    3. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    4. 5α-Reductase Inhibitors, Antiviral and Anti-Tumor Activities of Some Steroidal Cyanopyridinone Derivatives International Journal of Biological Macromolecules · 2011
    5. A Review on Steroidal 5α-Reductase Inhibitors for Treatment of Benign Prostatic Hyperplasia Current Medicinal Chemistry · 2011
    6. Synthesis, Antiproliferative Activity, Acute Toxicity and Assessment of the Antiandrogenic Activities of New Androstane Derivatives Archives of Pharmacal Research · 2011
    7. New Ester Derivatives of Dehydroepiandrosterone as 5α-Reductase Inhibitors Steroids · 2011
    8. Synthesis and Bioactivity of New Finasteride Conjugate Bioorganic & Medicinal Chemistry Letters · 2011
    9. Discovery of a Novel Hybrid from Finasteride and Epristeride as 5α-Reductase Inhibitor Bioorganic & Medicinal Chemistry Letters · 2010
    10. Determination of Rat 5α-Reductase Type 1 Isozyme Activity and Its Inhibition by Novel Steroidal Oxazolines Acta Biologica Hungarica · 2010
    11. 17-Oximino-5-Androsten-3β-yl Esters: Synthesis, Antiproliferative Activity, Acute Toxicity, and Effect on Serum Androgen Level Medicinal Chemistry Research · 2010
    12. Molecular Interactions of Progesterone Derivatives with 5α-Reductase Types 1 and 2 and Androgen Receptors Steroids · 2010
    13. Synthesis, Antiproliferative, Acute Toxicity and Assessment of Antiandrogenic Activities of Some Newly Synthesized Steroidal Lactams European Journal of Medicinal Chemistry · 2010
    14. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    15. Novel C-6 Substituted and Unsubstituted Pregnane Derivatives as 5α-Reductase Inhibitors and Their Effect on Hamster Flank Organs Diameter Size Steroids · 2009
    16. In Vivo and In Vitro Effect of Novel 4,16-Pregnadiene-6,20-Dione Derivatives as 5α-Reductase Inhibitors The Journal of Steroid Biochemistry and Molecular Biology · 2008
    17. Dutasteride Drugs · 2008
    18. Trends in the Development of New Drugs for the Treatment of Benign Prostatic Hyperplasia Current Medicinal Chemistry · 2006
    19. Discovery and Clinical Development of Dutasteride, a Potent Dual 5α-Reductase Inhibitor Current topics in medicinal chemistry · 2006
    20. Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors Current Medicinal Chemistry · 2005
    21. New 5α-Reductase Inhibitors: In Vitro and In Vivo Effects Steroids · 2005
    22. Synthesis and Pharmacological Evaluation of New Progesterone Esters as 5-Alpha-Reductase Inhibitors Chemical and Pharmaceutical Bulletin · 2005
    23. Steroid 5α-Reductase Inhibitors Mini-reviews in Medicinal Chemistry · 2003
    24. PNU 157706, A Novel Dual Type I and II 5α-Reductase Inhibitor The Journal of Steroid Biochemistry and Molecular Biology · 1998
    25. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP-Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996
    26. The Enzyme and Inhibitors of 4-Ene-3-Oxosteroid 5α-Oxidoreductase Steroids · 1995
    27. Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase Journal of Medicinal Chemistry · 1993

    Related research 3

    1. Steroidal 5α-Reductase and 17α-Hydroxylase/17,20-Lyase (CYP17) Inhibitors Useful in the Treatment of Prostatic Diseases The Journal of Steroid Biochemistry and Molecular Biology · 2013
    2. 5 Alpha-Reductase Inhibitors: What's New? Current opinion in urology · 2003
    3. The Clinical Development of a 5α-Reductase Inhibitor, Finasteride The Journal of Steroid Biochemistry and Molecular Biology · 1990