Studysummary This review examines the role of steroidal inhibitors in treating prostatic diseases but presents no new clinical results.
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Research cited in this study 27
- Synthesis and Biological Evaluation of Novel Unsaturated Carboxysteroids as Human 5α-Reductase Inhibitors: A Legitimate Approach European journal of medicinal chemistry · 2012
- Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-Diene or 4,6-Diene 20-Ones and 4-Azasteroid 20-Oximes Molecules · 2011
- The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
- 5α-Reductase Inhibitors, Antiviral and Anti-Tumor Activities of Some Steroidal Cyanopyridinone Derivatives International Journal of Biological Macromolecules · 2011
- A Review on Steroidal 5α-Reductase Inhibitors for Treatment of Benign Prostatic Hyperplasia Current Medicinal Chemistry · 2011
- Synthesis, Antiproliferative Activity, Acute Toxicity and Assessment of the Antiandrogenic Activities of New Androstane Derivatives Archives of Pharmacal Research · 2011
- New Ester Derivatives of Dehydroepiandrosterone as 5α-Reductase Inhibitors Steroids · 2011
- Synthesis and Bioactivity of New Finasteride Conjugate Bioorganic & Medicinal Chemistry Letters · 2011
- Discovery of a Novel Hybrid from Finasteride and Epristeride as 5α-Reductase Inhibitor Bioorganic & Medicinal Chemistry Letters · 2010
- Determination of Rat 5α-Reductase Type 1 Isozyme Activity and Its Inhibition by Novel Steroidal Oxazolines Acta Biologica Hungarica · 2010
- 17-Oximino-5-Androsten-3β-yl Esters: Synthesis, Antiproliferative Activity, Acute Toxicity, and Effect on Serum Androgen Level Medicinal Chemistry Research · 2010
- Molecular Interactions of Progesterone Derivatives with 5α-Reductase Types 1 and 2 and Androgen Receptors Steroids · 2010
- Synthesis, Antiproliferative, Acute Toxicity and Assessment of Antiandrogenic Activities of Some Newly Synthesized Steroidal Lactams European Journal of Medicinal Chemistry · 2010
- An Overview on 5α-Reductase Inhibitors Steroids · 2009
- Novel C-6 Substituted and Unsubstituted Pregnane Derivatives as 5α-Reductase Inhibitors and Their Effect on Hamster Flank Organs Diameter Size Steroids · 2009
- In Vivo and In Vitro Effect of Novel 4,16-Pregnadiene-6,20-Dione Derivatives as 5α-Reductase Inhibitors The Journal of Steroid Biochemistry and Molecular Biology · 2008
- Dutasteride Drugs · 2008
- Trends in the Development of New Drugs for the Treatment of Benign Prostatic Hyperplasia Current Medicinal Chemistry · 2006
- Discovery and Clinical Development of Dutasteride, a Potent Dual 5α-Reductase Inhibitor Current topics in medicinal chemistry · 2006
- Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors Current Medicinal Chemistry · 2005
- New 5α-Reductase Inhibitors: In Vitro and In Vivo Effects Steroids · 2005
- Synthesis and Pharmacological Evaluation of New Progesterone Esters as 5-Alpha-Reductase Inhibitors Chemical and Pharmaceutical Bulletin · 2005
- Steroid 5α-Reductase Inhibitors Mini-reviews in Medicinal Chemistry · 2003
- PNU 157706, A Novel Dual Type I and II 5α-Reductase Inhibitor The Journal of Steroid Biochemistry and Molecular Biology · 1998
- Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP-Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996
- The Enzyme and Inhibitors of 4-Ene-3-Oxosteroid 5α-Oxidoreductase Steroids · 1995
- Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase Journal of Medicinal Chemistry · 1993