Synthesis and Bioactivity of New Finasteride Conjugate

    April 2011 in “ Bioorganic & Medicinal Chemistry Letters ”
    Zhao Shuang, Wu Jiazhen, Yang Li-juan … Fang Xue-xun
    Studysummary In this study, a new Finasteride conjugate showed stronger inhibition of 5α-reductase and similar reduction of prostate hyperplasia in rats compared to Finasteride, with potentially improved toxicity.
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    Research cited in this study 4

    1. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    2. Anabolic Effects of Testosterone Are Preserved During Inhibition of 5α-Reductase Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism · 2007
    3. Inhibitors of 5α-Reductase in the Treatment of Benign Prostatic Hyperplasia Current pharmaceutical design · 2006
    4. The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1998

    Related research 2

    1. Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases International Journal of Dermatology · 1995
    2. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992