Molecular Interactions of Progesterone Derivatives with 5α-Reductase Types 1 and 2 and Androgen Receptors

    March 2010 in “ Steroids ”
    Eugene Bratoeff, Perla García, Yvonne Heuze … Marisa Cabeza
    Studysummary This study found that specific steroids, particularly 5 and 7b, decreased growth of prostate and seminal vesicles and bound to the androgen receptor, showing comparable pharmacological activity to finasteride.
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    Research cited in this study 2

    1. Effect of a Novel Steroid (PM-9) on the Inhibition of 5α-Reductase in Penicillium Crustosum Broths Steroids · 2003
    2. Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human Endocrinology · 1985

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    3. Molecular Interactions of Progesterone Derivatives with 5α-Reductase Types 1 and 2 and Androgen Receptors Steroids · 2010
    4. 5α-Reductase Isozymes and Androgen Actions in the Prostate Annals of the New York Academy of Sciences · 2009
    5. Expression and Activity Assay of Human Steroid 5 Alpha-Reductase Type II in CHO Cells Pharmaceutical biotechnology · 2004
    6. New Progesterone Esters as 5α-Reductase Inhibitors Chemical & Pharmaceutical Bulletin · 2001