Effect of a Novel Steroid (PM-9) on the Inhibition of 5α-Reductase in Penicillium Crustosum Broths

March 2003 in “ Steroids ”

Eugenio Flores, Marisa Cabeza, Alexandra Quiroz, Eugene Bratoeff, Genoveva Garcı́a, Elena Ramı́rez

5α-reductase finasteride dihydrotestosterone DHT PM-9 testosterone Propecia

TLDR PM-9 and finasteride effectively inhibit the enzyme that converts testosterone to DHT.

The study investigated the inhibition of the 5α-reductase enzyme in Penicillium crustosum broth by finasteride and a novel steroidal compound, PM-9. The enzyme, which converts testosterone to dihydrotestosterone (DHT), was inhibited in a competitive manner by both compounds. This research aimed to explore alternatives to animal testing for evaluating 5α-reductase inhibitors, which are relevant for treating conditions like benign prostatic hyperplasia and prostate cancer. The findings demonstrated that both finasteride and PM-9 effectively inhibited the enzyme in the broth, similar to their effects in animal models.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research New Progesterone Esters as 5α-Reductase Inhibitors

22 citations , January 2001 in “Chemical & Pharmaceutical Bulletin”

Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.

Related Community Posts Join

6 / 162 results

community Can I still save my hairline at age of 15?

in General 499 upvotes 1 month ago

A 15-year-old is concerned about hair loss, possibly at Norwood 2 or 3, and is using shampoos and conditioners recommended by a trichologist. Suggestions include considering topical minoxidil and consulting a doctor about topical anti-DHT treatments like finasteride or RU58841, but avoiding 5-alpha-reductase inhibitors at this age.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 2 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community 28M experiencing thinning - first timer here, please help

in Treatments 370 upvotes 3 weeks ago

A 28-year-old male experiencing hair thinning is considering minoxidil and finasteride. Minoxidil helps regrow hair, while finasteride prevents further loss; both are usually lifelong treatments.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 157 upvotes 2 years ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community risks with finasteride and dutasteride

in Research/Science 143 upvotes 5 months ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community Proof that finasteride messes with neurosteroids

in Research/Science 230 upvotes 1 year ago

Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

Related Research

6 / 6 results

research Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients After Finasteride Treatment for a Year

August 2021 in “Journal of The American Academy of Dermatology”

Finasteride treatment changes hormone levels in male pattern baldness patients.

research 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety

19 citations , April 2020 in “Dermatologic Therapy”

Dutasteride works better than finasteride for hair loss, with both being safe to use.

research A Review on Finasteride: A 5-Alpha Reductase Inhibitor, Its Mechanism, Facts, and Benefits

June 2019 in “Journal of Drug Delivery and Therapeutics”

Finasteride effectively treats hair loss and prostate issues with minimal side effects.

research The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia

65 citations , October 1999 in “Journal of The American Academy of Dermatology”

Finasteride effectively reduces hair loss by decreasing androgen levels.

research Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men

7 citations , August 1996 in “The Journal of Clinical Endocrinology and Metabolism”

research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness

61 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”