Effect of a Novel Steroid (PM-9) on the Inhibition of 5α-Reductase in Penicillium Crustosum Broths
March 2003
in “
Steroids
”
TLDR PM-9 and finasteride effectively inhibit the enzyme that converts testosterone to DHT.
The study investigated the inhibition of the 5α-reductase enzyme in Penicillium crustosum broth by finasteride and a novel steroidal compound, PM-9. The enzyme, which converts testosterone to dihydrotestosterone (DHT), was inhibited in a competitive manner by both compounds. This research aimed to explore alternatives to animal testing for evaluating 5α-reductase inhibitors, which are relevant for treating conditions like benign prostatic hyperplasia and prostate cancer. The findings demonstrated that both finasteride and PM-9 effectively inhibited the enzyme in the broth, similar to their effects in animal models.
