Synthesis and Pharmacological Evaluation of New Progesterone Esters as 5-Alpha-Reductase Inhibitors

    January 2005 in “ Chemical and Pharmaceutical Bulletin ”
    Elena Ramı́rez, Marisa Cabeza, Eugene Bratoeff … Teresa González Ramírez
    Studysummary This study reported that newly synthesized progesterone derivatives significantly reduced prostate weight in testosterone-treated hamsters, with 5alpha-reductase inhibitory activity dependent on the size of the substituent at C-17.
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    Research cited in this study 2

    1. Synthesis and Pharmacological Evaluation of New 16-Methyl Pregnane Derivatives Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin · 2002
    2. Pharmacology of Antiandrogens Journal of Steroid Biochemistry · 1986

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