New Ester Derivatives of Dehydroepiandrosterone as 5α-Reductase Inhibitors

    June 2011 in “ Steroids ”
    Yazmín Arellano, Eugene Bratoeff, Mariana Garrido … Marisa Cabeza
    Studysummary This study found that several dehydroepiandrosterone ester derivatives effectively reduced prostate and seminal vesicle weight in gonadectomized hamsters treated with testosterone, demonstrating potential antiandrogen effects comparable to Finasteride.
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    Research cited in this study 4

    1. Comparison Between Two Different Hamster Models Used for the Determination of Testosterone and Finasteride Activity Asian Journal of Animal and Veterinary Advances · 2010
    2. In Vivo and In Vitro Effect of Novel 4,16-Pregnadiene-6,20-Dione Derivatives as 5α-Reductase Inhibitors The Journal of Steroid Biochemistry and Molecular Biology · 2008
    3. New 5α-Reductase Inhibitors: In Vitro and In Vivo Effects Steroids · 2005
    4. Androgenic and Anti-Androgenic Effects of Progesterone Derivatives with Different Halogens as Substituents at the C-6 Position Steroids · 1999