Novel Type 1 5a-Reductase Inhibitors With Antiproliferative Potential On LNCaP Cells

June 2023 in “ Oriental Journal of Chemistry/Oriental journal of chemistry ”

Marisa Cabeza, Luis A. Menes, Evelyn Fuentes, Iván Bahena, Yvonne Heuze

type 1 5a-reductase inhibitors dehydroepiandrosterone derivatives testosterone dihydrotestosterone finasteride DHEA derivatives DHT

TLDR New compounds may help treat prostate cancer by reducing cell growth.

The study found that dehydroepiandrosterone derivatives 2a-b, 3a-f, and 4a-f significantly reduced the proliferation of LNCaP cells, a type of prostate cancer cell, compared to testosterone treatment. Unlike finasteride, these derivatives decreased cell viability and inhibited the conversion of testosterone to dihydrotestosterone at high concentrations. This suggests that these derivatives have potential as therapeutic agents for treating metastatic prostate cancer.

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Research cited in this study

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research Activity of Steroid 4 and Derivatives 4a–4f as Inhibitors of the Enzyme 5α-Reductase Type 1

3 citations, June 2018 in “Bioorganic & medicinal chemistry”

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

research Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor

70 citations, June 1993 in “Biochemistry”

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

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community Meta analysis: Topical or mesotherapy dutasteride is more effective than topical finasteride in the treatment of AGA in men

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Topical Dutasteride is more effective than topical Finasteride for treating AGA in men, with fewer side effects. Mesotherapy with Dutasteride, administered every 3 months, shows promising results for hair regrowth and maintenance without daily routines or significant side effects.

community Research Backed Dutasteride Simulator (Serum/scalp DHT included for all doses)

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community Research Backed Dutasteride Simulator (Serum/Scalp DHT included for all doses)

in Finasteride/Dutasteride 95 upvotes 4 weeks ago

A dutasteride simulator predicts that daily 0.5 mg dosing results in higher DHT suppression compared to less frequent dosing. Twice-weekly dutasteride may be as effective as finasteride 5 mg, providing a balance between efficacy and ease of use.

community Study shows further evidence that finasteride and dutasteride take 12-18 months or more to show significant results. Do NOT give up early

in Finasteride/Dutasteride 247 upvotes 1 year ago

The conversation discusses the effectiveness of finasteride and dutasteride in treating hair loss, emphasizing that significant results often take 12-18 months or more. Dutasteride is generally considered superior, with similar or fewer side effects than finasteride, but patience is required for noticeable improvement.

community A repository of links to current scientific research and findings into the nature of and relating to side-effects for Finasteride/Dutasteride/5a-reductase inhibitors.

in Finasteride 17 upvotes 5 years ago

Finasteride and dutasteride, used for hair loss, can cause sexual dysfunction, depression, and suicidal thoughts, with some effects persisting after stopping. The post stresses the importance of being aware of these risks.

community Massive study on finasteride side effects released

in Finasteride/Dutasteride 83 upvotes 1 year ago

The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

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research Evaluation of the Therapeutic Effects of AGA Drugs by Measuring Finasteride, Dutasteride, and Dihydrotestosterone in Hair

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Finasteride and dutasteride effectively reduce DHT in hair, which may help evaluate their treatment success for hair loss.

research The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia

65 citations, October 1999 in “Journal of The American Academy of Dermatology”

Finasteride effectively reduces hair loss by decreasing androgen levels.

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research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

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Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.