Novel Type 1 5a-Reductase Inhibitors With Antiproliferative Potential On LNCaP Cells

June 2023 in “ Oriental Journal of Chemistry/Oriental journal of chemistry ”

Marisa Cabeza, Luis A. Menes, Evelyn Fuentes, Iván Bahena, Yvonne Heuze

type 1 5a-reductase inhibitors dehydroepiandrosterone derivatives testosterone dihydrotestosterone finasteride DHEA derivatives DHT

TLDR New compounds may help treat prostate cancer by reducing cell growth.

The study found that dehydroepiandrosterone derivatives 2a-b, 3a-f, and 4a-f significantly reduced the proliferation of LNCaP cells, a type of prostate cancer cell, compared to testosterone treatment. Unlike finasteride, these derivatives decreased cell viability and inhibited the conversion of testosterone to dihydrotestosterone at high concentrations. This suggests that these derivatives have potential as therapeutic agents for treating metastatic prostate cancer.

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Research cited in this study

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research Activity of Steroid 4 and Derivatives 4a–4f as Inhibitors of the Enzyme 5α-Reductase Type 1

3 citations, June 2018 in “Bioorganic & medicinal chemistry”

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

research Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor

70 citations, June 1993 in “Biochemistry”

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

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Topical Dutasteride is more effective than topical Finasteride for treating AGA in men, with fewer side effects. Mesotherapy with Dutasteride, administered every 3 months, shows promising results for hair regrowth and maintenance without daily routines or significant side effects.

community Study shows further evidence that finasteride and dutasteride take 12-18 months or more to show significant results. Do NOT give up early

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The conversation discusses the effectiveness of finasteride and dutasteride in treating hair loss, emphasizing that significant results often take 12-18 months or more. Dutasteride is generally considered superior, with similar or fewer side effects than finasteride, but patience is required for noticeable improvement.

community A repository of links to current scientific research and findings into the nature of and relating to side-effects for Finasteride/Dutasteride/5a-reductase inhibitors.

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community Massive study on finasteride side effects released

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The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

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community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 8 months ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

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