Novel Type 1 5a-Reductase Inhibitors With Antiproliferative Potential On LNCaP Cells

June 2023 in “ Oriental Journal of Chemistry/Oriental journal of chemistry ”

Marisa Cabeza, Luis A. Menes, Evelyn Fuentes, Iván Bahena, Yvonne Heuze

type 1 5a-reductase inhibitors dehydroepiandrosterone derivatives testosterone dihydrotestosterone finasteride DHEA derivatives DHT

TLDR New compounds may help treat prostate cancer by reducing cell growth.

The study found that dehydroepiandrosterone derivatives 2a-b, 3a-f, and 4a-f significantly reduced the proliferation of LNCaP cells, a type of prostate cancer cell, compared to testosterone treatment. Unlike finasteride, these derivatives decreased cell viability and inhibited the conversion of testosterone to dihydrotestosterone at high concentrations. This suggests that these derivatives have potential as therapeutic agents for treating metastatic prostate cancer.

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