Effect of Flutamide and Two Novel Synthetic Steroids on GABA, Glutamine, and Some Oxidative Stress Markers in Rat Brain and Prostate

    January 2011 in “ Andrologia ”
    David Calderón Guzmán, Eugene Bratoeff, Erick Gómez Tagle López, Ernestina Hernández García, F. Pierdant Rioja, Norma Osnaya Brizuela, Francisca Trujillo Jiménez, Gerardo Barragán Mejía, Hugo Juárez Olguín, Daniel Santamaría del Ángel
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    TLDR Flutamide and a new synthetic steroid affected brain and prostate chemicals and showed potential for treating androgen-related conditions and epilepsy.
    The study examined the impact of flutamide, a steroid used for androgen-dependent conditions and as an antiepileptic, alongside two new synthetic steroids on GABA, glutamine, and oxidative stress markers in the brain and prostate of male Wistar rats. The rats were treated for 3 days, and the findings revealed various biochemical changes. Diazepam treatment led to increased GABA and serotonin levels but decreased glutamine. Progesterone treatment resulted in increased total ATPase activity. Flutamide treatment reduced lipid peroxidation, as indicated by lower TBARS levels, and one of the synthetic steroids, along with flutamide, decreased reduced glutathione (GSH). Testosterone increased prostate weight, while one novel synthetic steroid, 16ß-methyl-17α-benzoyloxypregnen-4-en-3,20-dione, showed promise for treating androgen-dependent diseases and epilepsy due to its antioxidant effects and influence on GABAergic and serotonergic metabolism. The exact number of rats involved in the study was not mentioned.
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