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Glossary Serotonin

neurotransmitter regulating mood, sleep, and appetite

Serotonin, also known as 5-HT or 5-Hydroxytryptamine, is a neurotransmitter that plays a crucial role in regulating mood, sleep, appetite, and other physiological functions. It is primarily found in the brain, bowels, and blood platelets, and imbalances in serotonin levels are often linked to conditions such as depression, anxiety, and migraines.

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research The cutaneous serotoninergic/melatoninergic system: securing a place under the sun

349 citations , January 2005 in “The FASEB journal”

This review discusses the cutaneous serotoninergic/melatoninergic system's potential role in skin function and resilience against environmental and internal stresses, but does not report new experimental findings.

research Serotoninergic and melatoninergic systems are fully expressed in human skin

249 citations , April 2002 in “The FASEB journal”

This study provides evidence that human skin contains genes and enzymes necessary for producing serotonin and melatonin.

research Characterization of the serotoninergic system in the C57BL/6 mouse skin

84 citations , July 2003 in “European journal of biochemistry”

This study found that mouse skin can produce and metabolize serotonin and N-acetylserotonin, with activity influenced by location, physiological skin status, cell type, and mouse strain.

research Histone deacetylase inhibitors promote neurosteroid‐mediated cell differentiation and enhance serotonin‐stimulated brain‐derived neurotrophic factor gene expression in rat C6 glioma cells

35 citations , April 2009 in “Journal of Neuroscience Research”

In this study, HDAC inhibitors promoted the differentiation of rat C6 glioma cells through the production of 5α‐reduced neurosteroids, enhancing serotonin-stimulated BDNF gene expression.

research Possible involvement of 5α-reduced neurosteroids in adrenergic and serotonergic stimulation of GFAP gene expression in rat C6 glioma cells

17 citations , April 2006 in “Brain Research”

This study found that stimulation with certain neurotransmitters and hormones suggests the involvement of 5α-reduced neurosteroids in glial cell differentiation in rat C6 glioma cells.

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