Establishment and Characterization of a Canine Keratinocyte Organoid Culture System

    July 2018 in “ Veterinary Dermatology ”
    Dominique J. Wiener, Onur Basak, Priyanca Asra … Hans Clevers
    Studysummary This study established a 3D in vitro culture system of canine keratinocyte organoids to study epidermal function and address skin disorders in dogs, though additional growth factors are needed for hair follicle development.
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    Research cited in this study 14

    1. Novel Insights Into the Pathways Regulating the Canine Hair Cycle and Their Deregulation in Alopecia X PLOS ONE · 2017
    2. Self-Organization Process in Newborn Skin Organoid Formation Inspires Strategy to Restore Hair Regeneration of Adult Cells Proceedings of the National Academy of Sciences of the United States of America · 2017
    3. In Vitro Skin Models to Study Epithelial Regeneration from the Hair Follicle PLoS ONE · 2017
    4. The Hair Follicle: Functions, Self-Renewal, and Alopecic Disorders Toxicologic pathology · 2016
    5. Epithelial Skin Biology: Stem Cells and Epidermal Homeostasis Current Topics in Developmental Biology · 2016
    6. Epidermolysis Bullosa in Animals: A Review Veterinary Dermatology · 2014
    7. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    8. Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin Cold Spring Harbor Perspectives in Medicine · 2014
    9. An Overview of Alopecias Cold Spring Harbor Perspectives in Medicine · 2014
    10. Epidermal Structure Created by Canine Hair Follicle Keratinocytes Enriched with Bulge Cells in a Three-Dimensional Skin Equivalent Model In Vitro: Implications for Regenerative Therapy of Canine Epidermis Veterinary dermatology · 2013
    11. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    12. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    13. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    14. Keratin 16 Expression Defines a Subset of Epithelial Cells During Skin Morphogenesis and the Hair Cycle Journal of Investigative Dermatology · 2002

    Related research 5

    1. Establishment and Characterization of a Canine Keratinocyte Organoid Culture System Veterinary Dermatology · 2018
    2. Association of Basonuclin With the Ability of Keratinocytes to Multiply and Absence of Terminal Differentiation The Journal of Cell Biology · 1994
    3. Modulation of the Differentiated Phenotype of Keratinocytes of the Hair Follicle and Epidermis Journal of Dermatological Science · 1994
    4. Epidermis Reconstructed from the Outer Root Sheath of Human Hair Follicle: Effect of Retinoic Acid Archives of Dermatological Research · 1993
    5. Biochemistry of Transglutaminases and Cross-Linking in the Skin Journal of Investigative Dermatology · 1983