In Vitro Skin Models to Study Epithelial Regeneration from the Hair Follicle

March 2017 in “ PLoS ONE ”

Nkemcho Ojeh, Baki Akgül, Marjana Tomic‐Canic, Michael P. Philpott, Harshad Navsaria

pilosebaceous units truncated hair follicles multilayered epidermis de-epidermalized dermis collagen-glycosaminoglycan epithelial regeneration stem cells hair follicle progenitor epithelial cells PSU THF DED C-GAG

Studysummary This study found that intact pilosebaceous units were more effective than truncated hair follicles at regenerating a multilayered epidermis in a de-epidermalized dermis in vitro.

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Research cited in this study

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research Endogenous Human Skin Equivalent Promotes In Vitro Morphogenesis of Follicle-Like Structures

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This study demonstrated that an engineered human skin equivalent can generate follicle-like structures resembling fetal skin, highlighting the role of the dermal compartment in directing epithelial cell fate in vitro.

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788 citations , February 2007 in “Nature”

This review explores how adult skin epithelia preserve stem cell populations for hair follicle regeneration and wound healing, but reports no new experimental results.

research Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis

1279 citations , November 2005 in “Nature Medicine”

Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

research Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

87 citations , February 2004 in “Plastic and Reconstructive Surgery”

In this study, researchers achieved complete reepithelialization and hair growth on a burn-injured scalp using a tissue-engineered dermal template with early micrograft hair follicle implantation.

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854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review summarizes recent advances in understanding the molecular mechanisms of hair follicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.

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949 citations , January 2001 in “Cell”

This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

In this study, researchers found that hair follicle stem cells in mice can generate both hair follicle and epidermis cells, highlighting their potential bipotency.

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221 citations , June 1999 in “In Vitro Cellular & Developmental Biology - Animal”

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198 citations , March 1999 in “Journal of Investigative Dermatology”

This study found that keratin 15 expression is downregulated in hyperproliferative conditions like psoriasis and hypertrophic scars, suggesting it is not compatible with keratinocyte activation.

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57 citations , October 1996 in “Dermatologic clinics”

This study found that using hyaluronic acid microneedles to deliver minoxidil significantly reduced hair loss in chemotherapy-induced alopecia mice, with only 10% of the dose used in topical applications.

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36 citations , October 1993 in “British Journal of Dermatology”

In this study, isolated human hair follicles maintained prolonged growth and consistent DNA and keratin synthesis patterns in a fully defined medium for at least 9 days while preserving in vivo-like morphology.

research Co-Culture of Human Hair Follicles and Dermal Papillae in a Collagen Matrix

36 citations , November 1990 in “The Journal of Dermatology”

This study found that dermal papilla cells in culture may enhance and attract follicular epithelial cell growth, suggesting their pivotal role in hair and follicle development.

research Human Hair Growth In Vitro

385 citations , November 1990 in “Journal of Cell Science”

This study successfully grew and maintained human hair follicles in vitro, noting that TGF-β1 negatively affects growth, while EGF replicates hair-removal effects seen in animals.