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GlossaryPilosebaceous Units

structures in skin containing hair follicle and oil gland

Pilosebaceous units are the structures in the skin that include a hair follicle, a sebaceous (oil) gland, and a small muscle called the arrector pili. These units are responsible for producing hair and sebum, an oily substance that helps keep the skin and hair moisturized. Understanding pilosebaceous units is crucial for professionals dealing with conditions like acne, hair loss, and other dermatological issues.

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research Culture of the Human Pilosebaceous Unit, Hair Follicle, and Sebaceous Gland

30 citations , April 2018 in “Experimental Dermatology”

The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.

research Re-Evaluating The Role Of Demodex Mite In Skin Bio-Balance

March 2022 in “Egyptian Academic Journal of Biological Sciences. E, Medical Entomology and Parasitology”

Demodex mites might help skin balance by eating bacteria, but their role in skin disorders is unclear and may involve other factors.

research Efficacy in Alopecia of an Anti-Hair Loss Conditioner with Serenoa Serrulata and Tocopherol. Pilot Study

November 2022 in “Medicina Estética Revista Científica de la Sociedad Española de Medicina Estética (SEME)”

The conditioner with Serenoa serrulata and tocoferol helps reduce hair loss.

The Evolution of Healthy Skin to Acne Lesions: A Longitudinal, In Vivo Evaluation with Reflectance Confocal Microscopy and Optical Coherence Tomography

research The Evolution of Healthy Skin to Acne Lesions: A Longitudinal, In Vivo Evaluation with Reflectance Confocal Microscopy and Optical Coherence Tomography

19 citations , April 2019 in “Journal of the European Academy of Dermatology and Venereology”

Acne lesions start with changes in hair follicles and increase in inflammation, suggesting a cycle that could affect treatment strategies.

research Special Focus Issue: Transdermal, Topical, and Follicular Drug Delivery Systems

5 citations , March 2016 in “Drug Development and Industrial Pharmacy”

New drug delivery systems improve treatment effectiveness and patient experience.

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community Scalp tension and thickness of the galea aponeurotica, inflammation and potential treatment pathways

in Research/Science 3 years ago

Scalp tension potentially affecting hair loss, and potential treatments for male pattern baldness such as Minoxidil, Finasteride and RU58841. Evidence from a study was discussed which suggests that the cause of MPB lies within the follicle itself and is not dependent on its surrounding environment.

community Opinions on Scalp fibrosis and DHT?

in Research/Science 9 upvotes 3 years ago

The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

community Why liposomal finasteride and minoxidil may be better than traditional topical solutions.

in Research/Science 2 upvotes 9 months ago

Liposomal formulations of finasteride and minoxidil may enhance drug delivery to the skin and hair follicles more effectively than traditional solutions, potentially improving treatment outcomes. However, more human clinical trials are needed to confirm these benefits.

community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

in Research/Science 3 upvotes 1 month ago

Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

community Phase II topical dut study - outperforms oral fin with a minor DHT reduction

in Research/Science 61 upvotes 1 month ago

Topical dutasteride 0.05% is more effective for hair growth than oral finasteride 1mg, with minimal DHT reduction. The formulation uses castor oil and MCTs for better absorption but is not widely available until 2028.

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