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Glossary Epithelial Regeneration

process of skin and organ lining cells repairing themselves

Epithelial regeneration refers to the process by which the epithelial cells, which form the outer layer of the skin and line various organs and structures in the body, repair and renew themselves after injury or damage. This process is crucial for maintaining the integrity and function of tissues, as it involves the proliferation and differentiation of stem cells to replace lost or damaged cells.

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Research

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research Plasticity of epithelial stem cells in tissue regeneration

479 citations , June 2014 in “Science”

This review discusses the plasticity of epithelial stem cells in regenerative contexts and reports no new research findings; the authors highlight potential implications for regenerative medicine and cancer.

research Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish

92 citations , March 2016 in “Developmental Cell”

Zebrafish skin regeneration relies on cell behaviors and reactive oxygen species, with antioxidants reducing and hydrogen peroxide increasing regeneration.

research Immune-Epithelial Cross Talk in Regeneration and Repair

52 citations , January 2023 in “Annual Review of Immunology”

This review discusses how immune mechanisms contribute to the regeneration and repair of epithelial tissues and highlights their potential role in both disease and therapeutic innovation; it reports no new clinical results.

research In vitro skin models to study epithelial regeneration from the hair follicle

19 citations , March 2017 in “PLoS ONE”

This study found that intact pilosebaceous units were more effective than truncated hair follicles at regenerating a multilayered epidermis in a de-epidermalized dermis in vitro.

research Scaffolds for epithelial and hair follicle regeneration

1 citations , January 2019 in “Elsevier eBooks”

This chapter reviews the use of electrospun matrices in creating tissue-engineered skin substitutes and reports no new clinical results; it emphasizes the need for a cell-friendly microenvironment.

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community Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling

23 upvotes 11 months ago

Fatty acid metabolic signaling can activate epithelial stem cells for hair regeneration. Oleic and palmitoleic acids showed the best results, but practical application on humans remains uncertain.

community Researchers working on ways to regenerate lost hair from stem cells identified a recipe for normal hair regeneration in the lab. “A method for cyclical regeneration of hair follicles from hair follicle stem cells and will help make hair follicle regeneration therapy a reality in the near future.”

263 upvotes 5 years ago

Hair loss treatments like finasteride, minoxidil, and hair transplants have side effects and limitations. There is hope for future advancements in stem cell therapy and hair follicle regeneration, though skepticism about their effectiveness and timeline persists.

community Hair cloning breakthrough, this might just be the big one ?

418 upvotes 7 months ago

Japanese scientists discovered ABM cells, enabling successful human hair follicle cloning, potentially curing hair loss. The treatment may be available in Japan by 2028, but it will be expensive and require travel.

community Proof DHT is not the main cause of hair loss. TRPS1 Gene and Protein might be. PP405 won’t work. AMP-303 might!

153 upvotes 6 months ago

Hair loss may be linked to the TRPS1 gene and protein, not just DHT. Amplifica's AMP-303 targets mesenchymal stem cells and shows promise in treating hair loss, unlike Pelage's PP405.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

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