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GlossaryLgr5

protein marker for adult stem cells in hair follicles

Lgr5, or Leucine-rich repeat-containing G-protein coupled receptor 5, is a protein that serves as a marker for adult stem cells in various tissues, including hair follicles. It plays a crucial role in the regeneration and repair of these tissues, making it significant in studies related to hair growth and alopecia.

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research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations , October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin

326 citations , February 2009 in “The American journal of pathology”

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

research Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF

117 citations , March 2017 in “Nature Communications”

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

research A Slow-Cycling LGR5 Tumor Population Mediates Basal Cell Carcinoma Relapse After Therapy

105 citations , October 2018 in “Nature”

A small group of slow-growing cells causes basal cell carcinoma to return after treatment.

research NEDD4 and NEDD4L Regulate Wnt Signaling and Intestinal Stem Cell Priming by Degrading LGR5 Receptor

91 citations , December 2019 in “The EMBO Journal”

NEDD4 and NEDD4L help control intestinal stem cells and prevent tumors by breaking down the LGR5 receptor.

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