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    Glossary Lgr5

    protein marker for adult stem cells in hair follicles

    Lgr5, or Leucine-rich repeat-containing G-protein coupled receptor 5, is a protein that serves as a marker for adult stem cells in various tissues, including hair follicles. It plays a crucial role in the regeneration and repair of these tissues, making it significant in studies related to hair growth and alopecia.

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    1. Lgr5 marks cycling, yet long-lived, hair follicle stem cells Nature Genetics · 2008 · 835 citations
    2. Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin ˜The œAmerican journal of pathology · 2009 · 326 citations
    3. Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF Nature Communications · 2017 · 117 citations
    4. A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy Nature · 2018 · 105 citations
    5. NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor The EMBO Journal · 2019 · 91 citations
    6. LGR5 is a Marker of Poor Prognosis in Glioblastoma and is Required for Survival of Brain Cancer Stem‐Like Cells Brain pathology · 2012 · 82 citations
    7. Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network Journal of Biological Chemistry · 2013 · 58 citations
    8. Stem cell plasticity enables hair regeneration following Lgr5+ cell loss Nature Cell Biology · 2017 · 56 citations
    9. Stimulation of the Follicular Bulge LGR5+ and LGR6+ Stem Cells with the Gut-Derived Human Alpha Defensin 5 Results in Decreased Bacterial Presence, Enhanced Wound Healing, and Hair Growth from Tissues Devoid of Adnexal Structures Plastic and Reconstructive Surgery · 2013 · 39 citations
    10. <i>Pten</i> loss in Lgr5<sup>+</sup> hair follicle stem cells promotes SCC development Theranostics · 2019 · 24 citations
    11. Distinct expression profile of stem cell markers, LGR5 and LGR6, in basaloid skin tumors Virchows Archiv · 2017 · 9 citations
    12. LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis Scientific Reports · 2022 · 8 citations
    13. Lgr5+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors Oncotarget · 2016 · 8 citations
    14. Promotion of mouse ameloblast proliferation by Lgr5 mediated integrin signaling Journal of Cellular Biochemistry · 2013 · 7 citations
    15. Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice Inflammation and Regeneration · 2023 · 7 citations
    16. Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice Journal of diabetes research · 2022 · 6 citations
    17. MmuPV1-Induced Cutaneous Squamous Cell Carcinoma Arises Preferentially from Lgr5+ Epithelial Progenitor Cells Viruses · 2022 · 2 citations
    18. LGR5 is a Conserved Marker of Hair Follicle Stem Cells Across Species and is Present Early and Throughout Follicle Morphogenesis Research Square (Research Square) · 2022
    19. Lgr5 Stem Cells and Potential Treatments for Hair Loss Theoretical and Natural Science · 2026
    20. In vitro hair growth‐promoting effect of Lgr5‐binding octapeptide in human primary hair cells Journal of Cosmetic Dermatology · 2023
    21. 231 Novel protocol for the invitro maintenance and expansion of adult epidermal LGR5+ stem cells Reproduction Fertility and Development · 2019
    22. Corneal Endothelial Cell Fate Is Maintained by LGR5 Through the Regulation of Hedgehog and Wnt Pathway Stem cells · 2013 · 73 citations
    23. Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis Oncogene · 2012 · 52 citations
    24. Coexistence of Quiescent and Active Adult Stem Cells in Mammals Science · 2010 · 1201 citations
    25. Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells Gastroenterology · 2010 · 291 citations
    26. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing Cell Reports · 2018 · 209 citations
    27. Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations Journal of Clinical Investigation · 2011 · 178 citations
    28. Diverse mechanisms for endogenous regeneration and repair in mammalian organs Nature · 2018 · 172 citations
    29. Genetic architecture of mouse skin inflammation and tumour susceptibility Nature · 2009 · 133 citations
    30. Ferreting out stem cells from their niches Nature Cell Biology · 2011 · 80 citations