TLDR Melatonin helped some Pomeranian dogs regrow hair, but it wasn't linked to estrogen receptors.
The study investigated the role of estrogen receptors in Pomeranian dogs with hair cycle arrest (alopecia X) treated with melatonin. Fifteen dogs were included, and biopsies were taken before and after 3 months of treatment. Histopathological findings included hyperkeratosis, follicular keratosis, and thin epidermis. After treatment, 40% of the dogs showed mild to moderate hair regrowth, but this was not associated with changes in estrogen receptor-α staining. The study concluded that hair regrowth in these dogs was not linked to a decrease in follicular estrogen receptors, suggesting the need for further research with more potent estrogen receptor blockers to understand hair cycle regulation in dogs with alopecia X.
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52 citations,
October 2004 in “Veterinary dermatology” Melatonin and mitotane treatment led to hair re-growth in 62% of dogs with Alopecia X, but this was not always linked to normal hormone levels.
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February 2000 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism” Estradiol stops hair growth in mice, but an antagonist can reverse this effect.
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December 1999 in “Journal of Investigative Dermatology Symposium Proceedings” 17-β-Estradiol applied to the skin stops hair growth, while ICI 182 780 helps hair grow in mice.
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May 2016 in “Experimental and Therapeutic Medicine” MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.
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April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
