TLDR Melatonin helped some Pomeranian dogs regrow hair, but it wasn't linked to estrogen receptors.
The study investigated the role of estrogen receptors in Pomeranian dogs with hair cycle arrest (alopecia X) treated with melatonin. Fifteen dogs were included, and biopsies were taken before and after 3 months of treatment. Histopathological findings included hyperkeratosis, follicular keratosis, and thin epidermis. After treatment, 40% of the dogs showed mild to moderate hair regrowth, but this was not associated with changes in estrogen receptor-α staining. The study concluded that hair regrowth in these dogs was not linked to a decrease in follicular estrogen receptors, suggesting the need for further research with more potent estrogen receptor blockers to understand hair cycle regulation in dogs with alopecia X.
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52 citations,
October 2004 in “Veterinary dermatology” Melatonin and mitotane treatment led to hair re-growth in 62% of dogs with Alopecia X, but this was not always linked to normal hormone levels.
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February 2000 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism” Estradiol stops hair growth in mice, but an antagonist can reverse this effect.
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May 2022 in “Frontiers in Cell and Developmental Biology” Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.
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May 2016 in “Experimental and Therapeutic Medicine” 29 citations,
April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
