Analysis of Histology and Long Noncoding RNAs Involved in the Rabbit Hair Follicle Density Using RNA Sequencing

January 2021 in “ BMC Genomics ”

Haisheng Ding, Huiling Zhao, Xiaowei Zhao, Yunxia Qi, Xiaofei Wang, Dongwei Huang

hair follicle density long noncoding RNAs RNA sequencing lipid metabolism apoptosis amino acid synthesis LNC_002171 KRTAP15-1

Studysummary This study found that high wool-producing Wan Strain Angora rabbits had higher hair follicle density and identified potential regulatory long noncoding RNAs that may influence this trait. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the molecular mechanisms regulating hair follicle density in Wan Strain Angora rabbits, focusing on differences between high and low wool production groups. It found that higher hair follicle density was associated with increased wool production. RNA sequencing identified 50 differentially expressed long noncoding RNAs (lncRNAs) and 38 genes, with significant enrichment in processes related to lipid metabolism, apoptosis, and amino acid synthesis. Specific lncRNAs and genes, such as LNC_002171 and KRTAP15-1, were highlighted as potential regulators of hair follicle density. The findings enhanced the understanding of lncRNA roles in hair follicle density regulation and provided insights into genetic factors affecting wool production, with implications for rabbit breeding programs.

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