TLDR TCHHL1 is a protein important for hair growth, found in hair follicles.
The study identified trichohyalin-like 1 (TCHHL1), a novel S100 fused-type protein, which was selectively expressed in hair follicles and localized specifically within the distal inner root sheath (IRS). TCHHL1 was an evolutionarily conserved gene, predating therian mammals, and suggested to play a fundamental role in hair morphogenesis. The research emphasized the importance of TCHHL1 in hair biology, indicating the need for future studies to explore its functional role in hair growth and development.
66 citations
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July 2010 in “Journal of Proteome Research” Trichohyalin may trigger the immune response causing alopecia areata.
234 citations
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November 2009 in “American journal of human genetics” Common variants in the Trichohyalin gene are linked to straight hair in Europeans.
1039 citations
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February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
8 citations
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July 2004 in “Journal of morphology” Marsupial hair structure and keratin distribution are similar to placental mammals.
146 citations
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May 2002 in “The American journal of pathology” Cathepsin L is essential for normal hair growth and development.
68 citations
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April 2014 in “Journal of Investigative Dermatology” Trichohyalin-like proteins are essential for the development of skin structures like hair, nails, and feathers.
5 citations
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September 2013 66 citations
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July 2010 in “Journal of Proteome Research” Trichohyalin may trigger the immune response causing alopecia areata.
February 2025 in “Animals” Understanding proteins in skin structures like claws and hair is crucial for future research.
5 citations
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December 2021 in “Frontiers in Cell and Developmental Biology” Enzymes called PADIs play a key role in hair growth and loss.
95 citations
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February 2019 in “The New England Journal of Medicine” Mutations in the PADI3 gene are linked to a higher risk of scarring hair loss in women of African descent.
