The Structure of Human Trichohyalin: Potential Multiple Roles as a Functional EF-Hand-Like Calcium-Binding Protein, a Cornified Cell Envelope Precursor, and an Intermediate Filament-Associated Cross-Linking Protein

    January 1993
    The University of North Carolina at Chapel Hill University Libraries
    TLDR Trichohyalin is a versatile protein involved in hair and skin structure.
    The study on human trichohyalin revealed that it is an intermediate filament-associated protein with a significant role in the inner root sheath cells of hair follicles and the granular layer of the epidermis. Researchers determined its full-length sequence using RNA-mediated anchored polymerase chain reaction methods and genomic cloning. Trichohyalin, a 248 kDa protein, was found to have one of the highest contents of charged residues among proteins, suggesting it may serve multiple functions: as a calcium-binding protein similar to EF-hand proteins, a precursor to the cornified cell envelope, and a cross-linking protein associated with intermediate filaments.
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