Hoxc13/β-Catenin Correlation with Hair Follicle Activity in Cashmere Goat

July 2012 in “ Journal of integrative agriculture/Journal of Integrative Agriculture ”

Jianzhong Wu, Yanjun Zhang, Jiaxin Zhang, Zi-li Chang, Jinquan Li, Zhen Yan, Husile, Wenguang Zhang

Hoxc13 β-catenin hair follicle development melatonin fibroblasts keratinocytes

Studysummary This study found that Hoxc13 gene expression, influenced by melatonin, was associated with hair follicle activity in Cashmere goats, with in vitro evidence suggesting effects on genes relevant to follicle development. Our plain-language summary of this paper — not a Tressless recommendation.

In a study from July 2012, researchers investigated the molecular mechanisms behind seasonal hair follicle activity in Cashmere goats. They focused on the expression of 19 genes, including Hoxc13 and β-catenin, which are believed to be associated with hair follicle development. The study found that Hoxc13 expression significantly increased between July and November when goats were treated with melatonin. Additionally, in vitro experiments showed that overexpressing Hoxc13 in fibroblasts and keratinocytes from Cashmere goat skin led to a decrease in genes that negatively affect hair follicle development and an increase in genes that positively affect it. These results suggest that Hoxc13 plays a role in regulating hair follicle activity and is influenced by seasonal changes and melatonin treatment.

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