TLDR Hoxc13 gene expression and skin thickness change similarly during cashmere goat hair follicle development.
The study investigated the expression pattern of the Hoxc13 gene in cashmere goat skin during hair follicle development. It found that the changes in Hoxc13 gene expression and skin thickness followed a similar trend during hair follicle morphogenesis. The researchers identified a 5.4 kb fragment in the Hoxc13 intron containing regulatory motifs and discovered a highly conserved region across mammals, with additional specific regions in livestock. They also examined potential pre-miRNA in this region, which could help understand the mechanisms regulating Hoxc13 gene expression.
65 citations,
July 2006 in “Journal of biological chemistry/The Journal of biological chemistry” The gene Foxq1, controlled by Hoxc13, is crucial for hair follicle differentiation.
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2 citations,
February 2022 in “Genomics” Researchers discovered new cell types in goat hair follicles that could help understand hair regrowth and human hair loss.
8 citations,
July 2020 in “BMC genomics” The research found genes that change during cashmere goat hair growth and could help determine the best time to harvest cashmere.
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14 citations,
January 2015 in “Genetics and molecular research” The transition from growth to regression in Cashmere goat hair follicles involves changes in expression of genes related to keratin and cell differentiation.
61 citations,
April 2013 in “PloS one” The study found key genes and pathways involved in cashmere goat hair growth stages.
22 citations,
July 2012 in “Journal of integrative agriculture/Journal of Integrative Agriculture” Hoxc13 is linked to seasonal hair growth in Cashmere goats and is affected by melatonin.
