Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling

April 2013 in “ PloS one ”

Rong Geng, Chao Yuan, Yulin Chen

TLDR The study found key genes and pathways involved in cashmere goat hair growth stages.

The study investigated differentially expressed genes (DEGs) in cashmere goat skin during hair follicle development and cycling using RNA-Seq, generating over 7.3 million clean reads per stage. It identified 1,332 DEGs across anagen, catagen, and telogen stages, with significant involvement of pathways like Wnt, Shh, TGF-β, and Notch. Key genes from the tumor necrosis factor family, chemokine family, and others were highlighted, with hepatocyte growth factor (HGF) and macrophage-stimulating protein (MSP) showing high expression during anagen and catagen. The study provided valuable insights into the molecular mechanisms of hair follicle development, laying a foundation for future research to potentially enhance cashmere production.

View this study on journals.plos.org →

Discuss this study in the Community →

Research cited in this study

20 / 20 results

research Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop

138 citations, June 2012 in “Genes & Development”

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

207 citations, March 2012 in “Development”

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

research Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

28 citations, October 2011 in “International Journal of Molecular Medicine”

Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.

research Endogenous Retinoids in the Hair Follicle and Sebaceous Gland

50 citations, September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

research Clock Genes, Hair Growth, and Aging

55 citations, March 2010 in “Aging”

Circadian clock genes are important for hair growth and may affect aging-related hair loss and graying.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations, February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Adenosine Increases Anagen Hair Growth And Thick Hairs In Japanese Women With Female Pattern Hair Loss: A Pilot, Double-Blind, Randomized, Placebo-Controlled Trial

research Adenosine Increases Anagen Hair Growth And Thick Hairs In Japanese Women With Female Pattern Hair Loss: A Pilot, Double-Blind, Randomized, Placebo-Controlled Trial

33 citations, December 2008 in “Journal of Dermatology”

Adenosine lotion improves hair growth and thickness in women with hair loss.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations, February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.

research Scratching the Surface of Skin Development

788 citations, February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research Genetic Basis of Skin Appendage Development

111 citations, January 2007 in “Seminars in cell & developmental biology”

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

research Biology of the Hair Follicle: The Basics

224 citations, March 2006 in “Seminars in Cutaneous Medicine and Surgery”

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

research Edar Signaling in the Control of Hair Follicle Development

71 citations, November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Edar signaling is crucial for proper hair follicle development and function.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations, January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

research Macrophage-Stimulating Protein Promotes Hair Growth Ex Vivo and Induces Anagen from Telogen Stage Hair Follicles In Vivo

25 citations, June 2004 in “Journal of Investigative Dermatology”

Macrophage-stimulating protein helps hair grow and can start hair growth phase in mice and human hair samples.

research Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling

277 citations, June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations, February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.

Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

research Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

83 citations, December 2001 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

research The Biology of Hair Follicles

1113 citations, August 1999 in “The New England Journal of Medicine”

Hair follicle biology advancements may lead to better hair growth disorder treatments.

Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

research Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

100 citations, November 1996 in “Molecular Medicine Today”

Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

research The Secret Life of the Hair Follicle

745 citations, February 1992 in “Trends in genetics”

Hair follicles create different cell layers and proteins, controlled by various molecules.

Related Research

3 / 3 results

Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus

research Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus

9 citations, February 2022 in “BMC Genomics”

Melatonin affects gene expression in goat hair follicles, potentially increasing cashmere production.

research Transcriptomic Analysis Reveals Critical Genes for the Hair Follicle of Inner Mongolia Cashmere Goat from Catagen to Telogen

25 citations, October 2018 in “PloS one”

Key genes regulate hair follicle phase changes in Inner Mongolia cashmere goats.

research Hair Follicle Transcriptome Profiles During the Transition from Anagen to Catagen in Cashmere Goat (Capra Hircus)

14 citations, January 2015 in “Genetics and molecular research”

The transition from growth to regression in Cashmere goat hair follicles involves changes in expression of genes related to keratin and cell differentiation.