Skin Transcriptome Reveals the Periodic Changes in Genes Underlying Hair Follicle Cycling in Cashmere Goats

August 2019 in “ Research Square (Research Square) ”

Zhihong Liu, Feng Yang, Meng Zhao, Qing Mu, Tianyu Che, Yuchun Xie, Lina Ma, Lu Mi, Jinquan Li, hong Yan Zhao

hair follicle cycling transcriptome sequencing quantitative PCR KAP3-1 KRTAP 8-1 KRTAP 24-1

Studysummary In this study, researchers found that the cashmere hair growth cycle is divided into three periods and key genes like KAP and KRTAP are positively correlated with these cycles in cashmere goats.

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The study on Inner Mongolia cashmere goats revealed that their hair growth cycle consisted of three distinct periods: growth (March-September), regression (September-December), and resting (December-March), with March marking the cycle's start. Transcriptome sequencing and quantitative PCR analysis identified key genes, including KAP3-1, KRTAP 8-1, and KRTAP 24-1, which showed a strong positive correlation with the cashmere growth cycle. These genes' expression was consistent with the cycle, although they followed a specific sequence, indicating their regulatory role in cashmere hair growth changes.

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Skin Transcriptome Reveals the Intrinsic Molecular Mechanisms Underlying Hair Follicle Cycling in Cashmere Goats Under Natural and Shortened Photoperiod Conditions

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