Skin Transcriptome Reveals the Periodic Changes in Genes Underlying Hair Follicle Cycling in Cashmere Goats

August 2019 in “ Research Square (Research Square) ”

Zhihong Liu, Feng Yang, Meng Zhao, Qing Mu, Tianyu Che, Yuchun Xie, Lina Ma, Lu Mi, Jinquan Li, hong Yan Zhao

TLDR Cashmere goats have a hair growth cycle with specific genes regulating growth, regression, and resting periods.

The study on Inner Mongolia cashmere goats revealed that their hair growth cycle consisted of three distinct periods: growth (March-September), regression (September-December), and resting (December-March), with March marking the cycle's start. Transcriptome sequencing and quantitative PCR analysis identified key genes, including KAP3-1, KRTAP 8-1, and KRTAP 24-1, which showed a strong positive correlation with the cashmere growth cycle. These genes' expression was consistent with the cycle, although they followed a specific sequence, indicating their regulatory role in cashmere hair growth changes.

View this study on researchsquare.com →

Discuss this study in the Community →

Research cited in this study

12 / 12 results

research Expression of Vimentin in Hair Follicle Growth Cycle of Inner Mongolian Cashmere Goats

23 citations , January 2018 in “BMC genomics”

Vimentin is involved in regulating the hair growth cycle in Inner Mongolian Cashmere goats.

Skin Transcriptome Reveals the Intrinsic Molecular Mechanisms Underlying Hair Follicle Cycling in Cashmere Goats Under Natural and Shortened Photoperiod Conditions

research Skin Transcriptome Reveals the Intrinsic Molecular Mechanisms Underlying Hair Follicle Cycling in Cashmere Goats Under Natural and Shortened Photoperiod Conditions

24 citations , October 2017 in “Scientific reports”

Changing light exposure can affect hair growth timing in goats, possibly due to a key gene, CSDC2.

research Expression of Fox-Related Genes in the Skin Follicles of Inner Mongolia Cashmere Goat

11 citations , June 2017 in “Asian-Australasian journal of animal sciences”

Fox genes are important for hair growth and development in cashmere goats.

research Biology of the Eyelash Hair Follicle: An Enigma in Plain Sight

34 citations , October 2015 in “British journal of dermatology/British journal of dermatology, Supplement”

Scientists don't fully understand eyelash hair follicle biology, including growth and color, and suggest more research is needed.

research Epidermal Stem Cells and Skin Tissue Engineering in Hair Follicle Regeneration

83 citations , January 2015 in “World Journal of Stem Cells”

Hair follicle regeneration needs special conditions and young cells.

research Leptin Controls Hair Follicle Cycling

25 citations , March 2014 in “Experimental Dermatology”

Leptin helps start the growth phase of hair.

research Transcriptome Sequencing Reveals Differences Between Primary and Secondary Hair Follicle-Derived Dermal Papilla Cells of the Cashmere Goat

81 citations , September 2013 in “PLoS ONE”

Primary and secondary hair follicle cells in Cashmere goats have different gene expressions affecting hair growth and size.

research Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling

61 citations , April 2013 in “PloS one”

The study found key genes and pathways involved in cashmere goat hair growth stages.

research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

176 citations , April 2011 in “Science”

Hair stem cell regeneration is controlled by signals that can explain different hair growth patterns and baldness.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research Genetic Basis of Skin Appendage Development

111 citations , January 2007 in “Seminars in cell & developmental biology”

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

research HKAP1.6 And HKAP1.7, Two Novel Human High Sulfur Keratin-Associated Proteins Are Expressed In The Hair Follicle Cortex

24 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Two new proteins, hKAP1.6 and hKAP1.7, are found in the hair follicle cortex.

Related Research

4 / 4 results

Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus

research Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus

9 citations , February 2022 in “BMC Genomics”

Melatonin affects gene expression in goat hair follicles, potentially increasing cashmere production.

research Transcriptomic Analysis Reveals Critical Genes for the Hair Follicle of Inner Mongolia Cashmere Goat from Catagen to Telogen

25 citations , October 2018 in “PloS one”

Key genes regulate hair follicle phase changes in Inner Mongolia cashmere goats.

research Blockade of S100A3 Activity Inhibits Murine Hair Growth

1 citations , January 2015 in “Genetics and Molecular Research”

Stopping S100A3 activity slows down hair growth in mice.

research Hair Follicle Transcriptome Profiles During the Transition from Anagen to Catagen in Cashmere Goat (Capra Hircus)

14 citations , January 2015 in “Genetics and molecular research”

The transition from growth to regression in Cashmere goat hair follicles involves changes in expression of genes related to keratin and cell differentiation.