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Glossary Gene Ontology

standardized system categorizing gene functions across species

Gene Ontology (GO) is a comprehensive framework that organizes information about gene functions across different species. It categorizes genes into three main aspects: biological processes (what the gene product does), cellular components (where the gene product is active), and molecular functions (how the gene product acts). This standardized vocabulary helps researchers understand gene roles and interactions, facilitating cross-species comparisons and enhancing biological research.

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Research

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research Using WGCNA (weighted gene co-expression network analysis) to identify the hub genes of skin hair follicle development in fetus stage of Inner Mongolia cashmere goat

16 citations , December 2020 in “PloS one”

In this study, WNT10A was identified as a key gene in the development and maturation of skin hair follicles in fetal Inner Mongolian cashmere goats.

research Differential gene expression profiles in foetal skin of Rex rabbits with different wool density

4 citations , September 2016 in “World Rabbit Science”

This study observed that gene expression differences in Rex rabbits with varying wool densities suggest the involvement of specific genes and signaling pathways, including Shh and Eph, in hair follicle development.

research Investigation of Transcriptional Gene Profiling in Normal Murine Hair Follicular Substructures Using Next-Generation Sequencing to Provide Potential Insights into Skin Disease

1 citations , February 2016 in “Cell Transplantation”

In this study, researchers found that hair follicles and dermal fibroblasts, including dermal papilla cells, supported sustained hair growth in transplanted murine models, with RNA-seq analysis revealing active signaling pathways and gene expression patterns.

research Urological Oncology: Prostate Cancer

August 2010 in “The Journal of urology/The journal of urology”

This article discusses the potential role of dutasteride in prostate cancer prevention, examining its effects on risk, but does not report new clinical findings.

research MendelVar: gene prioritization at GWAS loci using phenotypic enrichment of Mendelian disease genes

2 citations , April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

This article discusses the MendelVar webserver, which integrates Mendelian disease data with GWAS findings to prioritize candidate genes for complex traits and reports no new experimental results.

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community How far are we from gene editing stem cells and implanting them?

in Research/Science 14 upvotes 6 months ago

Gene editing for hair loss is not yet viable due to technological and economic challenges. Current treatments like Minoxidil, finasteride, and hair transplants remain the most practical options.

community Seeking Suggestions for VEGF Gene Therapy in Hair Transplants

in Research 112 upvotes 5 months ago

A user is exploring VEGF gene therapy to enhance hair transplant results, considering measuring hair shaft diameter and growth rate. Suggestions include using phototrichograms and possibly adding PRP, though its effectiveness is uncertain.

community Proof DHT is not the main cause of hair loss. TRPS1 Gene and Protein might be. PP405 won’t work. AMP-303 might!

153 upvotes 6 months ago

Hair loss may be linked to the TRPS1 gene and protein, not just DHT. Amplifica's AMP-303 targets mesenchymal stem cells and shows promise in treating hair loss, unlike Pelage's PP405.

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