Expression of Steroidogenic Enzymes in Human Sebaceous Glands

    June 2014 in “ Journal of Endocrinology/Journal of endocrinology ”
    Tsukasa Inoue, Yasuhiro Miki, Shingo Kakuo … Hironobu Sasano
    Studysummary This study found that local androgen biosynthesis and metabolism in human sebaceous glands play a crucial role in sebum synthesis and secretion.
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    Research cited in this study 11

    1. Sex Steroid Synthesis in Human Skin In Situ: The Roles of Aromatase and Steroidogenic Acute Regulatory Protein in the Homeostasis of Human Skin Molecular and Cellular Endocrinology · 2012
    2. Selective Induction of Apoptosis in the Hamster Flank Sebaceous Gland Organ by a Topical Liposome 5-Alpha-Reductase Inhibitor: A Treatment Strategy for Acne Journal of Dermatology · 2010
    3. Role of Insulin, Insulin-Like Growth Factor-1, Hyperglycemic Food, and Milk Consumption in the Pathogenesis of Acne Vulgaris Experimental dermatology · 2009
    4. Hormonal Therapy for Acne Seminars in Cutaneous Medicine and Surgery · 2008
    5. The Human Skin as a Hormone Target and an Endocrine Gland Hormones · 2004
    6. Human Skin Is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1) Journal of Investigative Dermatology · 2003
    7. Glycerol Regulates Stratum Corneum Hydration in Sebaceous Gland Deficient (Asebia) Mice Journal of Investigative Dermatology · 2003
    8. Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    9. Intracrinology and the Skin Hormone Research in Paediatrics · 2000
    10. Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase Predominates in Human Sebaceous Glands Journal of Investigative Dermatology · 1998
    11. The Human Sebocyte Culture Model Provides New Insights Into Development and Management of Seborrhoea and Acne Dermatology · 1998