Expression of Steroidogenic Enzymes in Human Sebaceous Glands

June 2014 in “ Journal of Endocrinology/Journal of endocrinology ”

Tsukasa Inoue, Yasuhiro Miki, Shingo Kakuo, Akira Hachiya, Takashi Kitahara, Setsuya Aiba, Christos C. Zouboulis, Hironobu Sasano

17β-hydroxysteroid dehydrogenase type 2 17β-HSD2 peroxisome proliferator-activated receptor gamma PPARγ sebocytes androstenedione testosterone dihydrotestosterone DHT dehydroepiandrosterone DHEA insulin-like growth factor 1 IGF1 mammalian target of rapamycin mTOR sebum sebum secretion acne

Studysummary This study found that local androgen biosynthesis and metabolism in human sebaceous glands play a crucial role in sebum synthesis and secretion.

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