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research Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice

22 citations , August 2013 in “Experimental Dermatology”

In this study, the researchers found that constitutive activation of the EGFR in mice led to increased sebum production, enlarged sebaceous glands, and altered gene expression related to sebocyte proliferation and lipogenesis.

research Inhibition of lipogenesis and sebum secretion for Lotus corniculatus seed extract in vitro and in vivo

1 citations , November 2022 in “International Journal of Cosmetic Science”

In this study, a topical application of Lotus corniculatus seed extract significantly reduced sebum production and skin oiliness in humans through inhibition of lipid synthesis pathways.

research P133 : Case-control study: the effects of synthetic ceramide on dandruff, erythema, sebum secretion and water loss of scalp

January 2019 in “프로그램북(구 초록집)”

This study found that synthetic ceramide shampoo improved dandruff and erythema while reducing water loss when compared to control in a group of 20 subjects over four weeks.

research Intradermal Botulinum Toxin A Injection for Scalp Sebum Secretion Regulation: A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Prospective Study in Chinese Subjects

4 citations , August 2022 in “Aesthetic Surgery Journal”

This study found that one session of intradermal botulinum toxin type A injection decreased scalp sebum secretion and perception of greasiness more effectively than saline for up to 3 months.

research Minoxidil and male-pattern alopecia: a potential role for a local regulator of sebum secretion with vasoconstrictive effects?

5 citations , November 1999 in “Medical Hypotheses”

Minoxidil, a common hair loss treatment, might work by counteracting a hormone that reduces hair growth and promotes hair loss.

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Community Join

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community Taiwan scientists used naturally derived fatty acids serum to regrow hairs (in mice <.<)

96 upvotes 11 months ago

A serum with oleic and palmitoleic acids shows promise for hair regrowth in mice, but its effectiveness in humans is unproven. Minoxidil and finasteride remain the recommended treatments.

community Looking for clarification on Section 8 of the Comprehensive Microneedling Guide

3 upvotes 1 year ago

The conversation discusses the steps for microneedling, specifically differentiating between medical needling (0.5-1.5mm) and cosmetic needling (0.3mm). It emphasizes the importance of cleaning and disinfecting before microneedling, regardless of needle length.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community Ru58841 cleared my forehead acne

in Treatment 8 upvotes 1 year ago

RU58841 helped clear forehead acne. The user mixes it with 5% minoxidil and considers making a cream for acne treatment.

community anti-androgens help with chronic seborric dermatitis ?! and hence diffuse thinning

7 upvotes 1 year ago

An 18-year-old experiencing hair loss and seborrheic dermatitis has tried finasteride, dutasteride, and various shampoos without success. They are considering anti-androgens like RU58841 and KX-826 for oil control and dandruff reduction.

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Learn

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learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Hyaluronic Acid

What’s the difference between using hyaluronic acid as a serum on the scalp versus taking it as a supplement? A serum sits on the scalp surface. Oral hyaluronic acid has small trials on facial wrinkles, none on the scalp or hair.

learn Baicapil

Could a daily serum with Baicapil help revive dormant hair follicles before it’s too late? There is no independent evidence that Baicapil revives dormant follicles; the only human data are the supplier's own unpublished test. A dermatologist can tell whether follicles are still active and which treatments have evidence.

learn Bimatoprost

Can a lash-growth serum like bimatoprost actually work for your scalp? Bimatoprost (Latisse) is FDA-approved only for eyelashes, not the scalp. In the larger of two Allergan phase 2 scalp trials, every bimatoprost formulation gave smaller hair-count gains than minoxidil 5%; the results were posted to ClinicalTrials.gov but never published in a journal, and scalp use remains off-label and experimental.

learn Exosomes

Are exosomes applied as a serum, an injection, or combined with other hair treatments? Clinics offer exosomes as scalp injections, as serums applied after microneedling, or combined with PRP. No exosome product is FDA-approved, and no reliable evidence shows that any of these methods works.

learn Rapamycin

Are there any visible side effects when using rapamycin cream or serum on the scalp? No study has tested rapamycin on the scalp; in facial trials skin reactions were common (64% vs 29% placebo; Aitken et al. 2023, PMID 37463422).

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